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在乳腺癌中重建免疫监视:分子病理生理学与当前免疫治疗策略

英文原题:Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies.

查看英文原题

Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies.

PubMed 2021/11/06(内容时间) Int J Mol Sci Q1 · IF 5.6(JCR 2025)

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中文摘要

在过去50年中,乳腺癌免疫治疗已成为一个活跃的研究领域,为该疾病带来了新型靶向治疗。免疫治疗在提高乳腺癌生存率方面具有巨大潜力,尤其是对于预后最差的亚型。在此,我们综述了癌症逃避免疫破坏的机制,以及乳腺癌免疫治疗的历史和近期进展,包括塑造该疾病治疗的临床试验,重点关注细胞疗法、疫苗、检查点抑制剂和溶瘤病毒。

展开英文摘要原文

Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses.

Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.

论文信息

作者
Cilibrasi C、Papanastasopoulos P、Samuels M、Giamas G
单位
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.United Kingdom
文献类型
综述
期刊
International journal of molecular sciences2021 Nov 6
原文标识
PubMed 34769447 · DOI 10.3390/ijms222112015