CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Anterior chamber infiltration of CAR T-cells.
Anterior chamber infiltration of CAR T-cells.
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一名2岁白血病婴儿接受CD19 CAR-T 细胞治疗后,前房浸润的独特影像。尽管最初存在显著淋巴细胞减少且类似真菌感染,但前房液活检和细胞学分析证实这是CAR-T 细胞浸润,可能靶向了我们治疗医生未知的微小白血病。这是一个在两方面独特的病例:首先,说明了CAR-T 细胞运输的高质量;其次——鉴于目前这些细胞的广泛使用,该影像可能有助于教育临床医生认识这一潜在诊断。
A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians.
This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second - given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.
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