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CAR-T 细胞的前房浸润

英文原题:Anterior chamber infiltration of CAR T-cells.

查看英文原题

Anterior chamber infiltration of CAR T-cells.

PubMed 2021/10/22(内容时间) Am J Ophthalmol Case Rep

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中文摘要

一名2岁白血病婴儿接受CD19 CAR-T 细胞治疗后,前房浸润的独特影像。尽管最初存在显著淋巴细胞减少且类似真菌感染,但前房液活检和细胞学分析证实这是CAR-T 细胞浸润,可能靶向了我们治疗医生未知的微小白血病。这是一个在两方面独特的病例:首先,说明了CAR-T 细胞运输的高质量;其次——鉴于目前这些细胞的广泛使用,该影像可能有助于教育临床医生认识这一潜在诊断。

展开英文摘要原文

A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians.

This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second - given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.

论文信息

作者
Jacoby E、Zloto O、Vishnevskia Dai V
第一作者单位
Division of Pediatric Hematology, Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.Israel
通讯作者单位
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.Israel
期刊
American journal of ophthalmology case reports2021 Dec
原文标识
PubMed 34746512 · DOI 10.1016/j.ajoc.2021.101223