CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用活体成像深入探究肿瘤免疫治疗的作用机制
英文原题：Diving into the mechanism of action of tumor immunotherapies with intravital imaging.
查看英文原题
Diving into the mechanism of action of tumor immunotherapies with intravital imaging.
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中文摘要
肿瘤靶向单克隆抗体、免疫检查点阻断剂或CAR-T 细胞等肿瘤免疫疗法取得的临床成功和引发的巨大希望，要求我们更深入地了解这些治疗在患者体内究竟如何发挥作用。掌握这类详细机制对于优化治疗疗效、扩大可从治疗中获益的癌症患者人数至关重要。本综述旨在阐明，活体双光子成像可提供关于肿瘤免疫疗法作用机制的独特见解，并帮助识别其体内关键瓶颈。此外，本文讨论在肿瘤微环境中对免疫细胞、肿瘤亚克隆和细胞因子动态变化进行时空观察，如何推动抗肿瘤免疫应答新概念的形成。
展开英文摘要原文
The clinical successes and tremendous hopes raised by tumor immunotherapies such as tumor-targeting monoclonal antibodies, immune checkpoint blockers, or CAR T cells demand that we better understand how these treatments precisely act in the patient body.
Such a detailed knowledge is indeed essential to optimize therapeutical efficacy and maximize the number of cancer patients that could benefit from these therapies. This review aims to illustrate that intravital two-photon imaging is providing unique insights into the mode of action of tumor immunotherapies and is helping identify their critical bottlenecks in vivo.
Moreover, this article discusses how spatiotemporal observations of immune cells, tumor subclones, and cytokine dynamics in the tumor microenvironment may contribute to the emergence of new concepts in anti-tumor immune responses.
论文信息
- 作者
- Bousso P
- 单位
- Institut Pasteur, INSERM U1223, Equipe Labellisée Ligue Contre le Cancer, Université de Paris, Paris, France.France
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- Immunological reviews2022 Mar
- 原文标识
- PubMed 34713901 · DOI 10.1111/imr.13032