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通过单细胞测序检测正常细胞中嵌合抗原受体治疗靶点的表达可能促成脱靶毒性

英文原题:Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.

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Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.

PubMed 2021/10/21(内容时间) Cancer Cell Q1 · IF 56.1(JCR 2025)

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论文信息

作者
Jing Y、Liu Y、Li Q、Ye Y、Diao L、Huang Y、Zhou Y、Green MR
第一作者单位
Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yingjing@sjtu.edu.cn.China
通讯作者单位
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA; Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA. Electronic address: leng.han@tamu.edu.United States
文献类型
读者来信 · 美国 NIH 资助研究 · 非美国政府资助研究
期刊
Cancer cell2021 Dec 13
原文标识
PubMed 34678153 · DOI 10.1016/j.ccell.2021.09.016