RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
缺氧对癌症免疫状态的影响
英文原题：The impact of hypoxia on immune state in cancer.
查看英文原题
The impact of hypoxia on immune state in cancer.
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中文摘要
缺氧是实体瘤的一个已知特征，也是肿瘤标志性特征的关键促进因素。缺氧以有利于免疫逃逸和抵抗的方式影响肿瘤免疫。肿瘤微环境（TME）中的极度缺氧和异常缺氧诱导因子-1（HIF-1）活性是有效免疫治疗的障碍。在这种条件下，CD8+ T细胞的浸润和活性降低，而调节性T细胞（Tregs）和髓源性抑制细胞（MDSCs）则表现出高活性。高度缺氧的TME还损害树突状细胞（DCs）和自然杀伤（NK）细胞的成熟和活性。此外，缺氧TME与免疫系统细胞的代谢变化呈正相关。这些改变表明需要将缺氧调节作为免疫检查点抑制剂（ICI）治疗的补充靶向策略。
展开英文摘要原文
Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks. Hypoxia influences tumor immunity in a way favoring immune evasion and resistance. Extreme hypoxia and aberrant hypoxia-inducible factor-1 (HIF-1) activity in tumor microenvironment (TME) is a drawback for effective immunotherapy.
Infiltration and activity of CD8 + T cells is reduced in such condition, whereas regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) show high activities. Highly hypoxic TME also impairs maturation and activity of dendritic cell (DCs) and natural killer (NK) cells.
In addition, the hypoxic TME positively is linked positively with metabolic changes in cells of immune system. These alterations are indicative of a need for hypoxia modulation as a complementary targeting strategy to go with immune checkpoint inhibitor (ICI) therapy.
论文信息
- 作者
- Mortezaee K、Majidpoor J
- 单位
- Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: mortezaee.k@muk.ac.ir.Iran
- 文献类型
- 综述
- 期刊
- Life sciences2021 Dec 1
- 原文标识
- PubMed 34662552 · DOI 10.1016/j.lfs.2021.120057