通过靶向肿瘤相关巨噬细胞的嵌合受体工程化溶瘤病毒重振内源性抗肿瘤免疫
Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Emerging Therapies in the Treatment of Advanced Melanoma.
Emerging Therapies in the Treatment of Advanced Melanoma.
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免疫治疗和靶向治疗的巨大进步已经彻底改变了以往难以治疗的晚期黑色素瘤的管理。尽管这些子领域持续取得进展,但瘤内溶瘤治疗、过继细胞治疗和疫苗治疗的新方法正在被开发作为辅助或替代方案。与此同时,细胞因子也正在重新崛起为一种可行的选择。在未来几年内,一系列有效的药物将为治疗提供选择,不仅限于辅助治疗或不可切除的情况,还包括新辅助治疗的情况。也许,还包括早期黑色素瘤。
Great strides in immunotherapy and targeted therapy have revolutionized the management of previously devastating, advanced melanomas. Although these subfields continue to progress, novel approaches in intratumoral oncolytic therapy, adoptive cell therapy, and vaccine therapies are being developed as adjuncts or alternatives.
Cytokines, meanwhile, are seeing a resurgence as a viable option as well. The array of effective agents will, in the next few years, provide options for therapy not only in the adjuvant or unresectable settings but also in the neoadjuvant settings. Perhaps, too, in earlier stage melanomas.
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