CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Therapeutic cancer vaccines: reasons to believe.
Therapeutic cancer vaccines: reasons to believe.
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我们利用免疫系统力量控制肿瘤的希望已部分实现，这得益于抗PD1抗体及其他检查点抑制剂，以及使用嵌合抗原受体靶向谱系特异性表面标志物的工程化T细胞。这些成功能否被推广？治疗性癌症疫苗旨在教育或再教育免疫系统识别肿瘤特异性或肿瘤相关抗原。经历多次虚假曙光后，这种方法在晚期实体瘤中的有效性开始出现一些积极数据，尽管是作为与检查点抑制剂的联合疗法。但该领域是否靶向了正确的抗原？在低疾病负担患者中，使用最有效的疫苗平台靶向某些抗原集的干预措施，作为单一药物可能为患者带来令人印象深刻的长期益处。
Our hopes of using the power of the immune system to control tumours have been partially fulfilled with anti-PD1 antibodies and other checkpoint inhibitors and the use of engineered T cells targeting lineage-specific surface markers with chimeric antigen receptors. Can these successes be generalised?
Therapeutic cancer vaccines aim to educate or re-educate the immune system to recognise tumour specific or tumour associated antigens. After many false dawns, some positive data for the effectiveness of such an approach is starting to emerge in advanced solid tumours, albeit as combination therapies with checkpoint inhibitors.
But is the field targeting the right antigens? Interventions using the most effective vaccine platforms to target certain sets of antigens in patients with low disease burden might bring impressive long-term benefits to patients as single agents.
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