CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
以额叶为主并伴早期重复书写症的脑病作为 CAR-T 细胞治疗相关神经毒性的特征性标志
英文原题：Frontal predominant encephalopathy with early paligraphia as a distinctive signature of CAR T-cell therapy-related neurotoxicity.
查看英文原题
Frontal predominant encephalopathy with early paligraphia as a distinctive signature of CAR T-cell therapy-related neurotoxicity.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法是一种新兴疗法，对难治性血液系统恶性肿瘤疗效显著，但治疗相关毒性（包括神经毒性）可能限制其获益。及时积极治疗对于预防神经系统后遗症至关重要，但也可能干扰CAR-T 细胞的抗癌作用。本文描述4名接受CAR-T 细胞输注的患者，他们早期出现反复书写行为，即书写重复症（paligraphia），作为神经毒性的早期表现，随后均发生以额叶受累为主的脑病（1例轻度，3例重度）。书写重复症可能是CAR-T 细胞治疗相关神经毒性的早期、特异且易于识别的临床表现，并可能为临床处置提供参考。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy is an emerging highly effective treatment for refractory haematological malignancies. Unfortunately, its therapeutic benefit may be hampered by treatment-related toxicities, including neurotoxicity. Early aggressive treatment is paramount to prevent neurological sequelae, yet it potentially interferes with the anti-cancer action of CAR T-cells.
We describe four CAR T-cells infused patients who presented with reiterative writing behaviours, namely paligraphia, as an early manifestation of neurotoxicity, and eventually developed frontal predominant encephalopathy (one mild, three severe). Paligraphia may represent an early, specific, and easily detectable clinical finding of CAR T-cell therapy-related neurotoxicity, potentially informing its management.
论文信息
- 作者
- Pensato U、Amore G、D'Angelo R、Rinaldi R、Nicodemo M、Rondelli F、Mondini S、Santoro R
- 第一作者单位
- Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italia.Italy
- 通讯作者单位
- IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bellaria Hospital, Via Altura 3, 40139, Bologna, Italy. maria.guarino@aosp.bo.it.Italy
- 期刊
- Journal of neurology2022 Feb
- 原文标识
- PubMed 34424399 · DOI 10.1007/s00415-021-10766-5
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