RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
抗体片段与靶向结直肠癌治疗：全球系统综述
英文原题：Antibody Fragment and Targeted Colorectal Cancer Therapy: A Global Systematic Review.
查看英文原题
Antibody Fragment and Targeted Colorectal Cancer Therapy: A Global Systematic Review.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
研究概要
与放疗、化疗和手术等常用治疗相比，抗体类疗法被证明在结直肠癌治疗中极具前景。
中文摘要
背景与目的
抗体类疗法已显示出治疗结直肠癌患者的良好前景。然而，抗体分子量较大且半衰期长，可能给临床研究中的可重复生产带来限制。因此，新型治疗方法通常对常规抗体进行缩小和工程化改造，制成Fab、scFv、纳米抗体、双功能抗体、双特异性抗体、小抗体和双抗体等片段，以保留其高亲和力和高特异性，并用于靶向药物纳米颗粒偶联物。本系统综述首次旨在阐明多种抗体片段在结直肠癌治疗中的作用。
方法
系统检索Web of Science、PubMed、Scopus、Google Scholar和ProQuest，并审查文献参考列表以确定相关论文。全文检索纳入1990至2021年发表的英文文章。
结果
纳入的53项研究大多在体外开展；在多数研究中，单链抗体是最常用的抗体片段。多数抗体靶向癌胚抗原（CEA）治疗结直肠癌。另有大量研究观察到凋亡诱导和肿瘤生长抑制。此外，少数研究提示，先天免疫系统可通过增强NK细胞杀伤，间接影响肿瘤生长。
结论
与放疗、化疗和手术等常见治疗相比，抗体类疗法在结直肠癌治疗中展现出巨大前景。这种特异性癌症治疗还可激活先天免疫和特异性免疫，清除肿瘤细胞。
展开英文摘要原文
METHODS
A systematic literature search in the web of sciences, PubMed, Scopus, Google Scholar, and ProQuest was conducted. Reference lists of the articles were reviewed to identify the relevant papers. The full-text search included articles published in English during 19902021.
RESULTS
Most of the 53 included studies were conducted in vitro and in most conducted studies singlechain antibodies were among the most used antibody fragments. Most antibodies targeted CEA in the treatment of colorectal cancer. Moreover, a large number of studies observed apoptosis induction and tumor growth inhibition. In addition, few studies implicated the role of the innate immune system as an indirect mechanism of tumor growth by enhancing NK-cell killing.
CONCLUSION
Antibody-based therapy was demonstrated to be of great promise in the treatment of colorectal cancer rather than common treatments such as radiotherapy, chemotherapy, and surgical operations. This type of specified cancer treatment can also induce the activation of the innate and specific immune systems to eradicate tumor cells.
论文信息
- 作者
- Ghani S、Deravi N、Pirzadeh M、Rafiee B、Gatabi ZR、Bandehpour M、Yarian F
- 第一作者单位
- Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Iran
- 通讯作者单位
- Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Iran
- 文献类型
- 系统综述
- 期刊
- Current pharmaceutical biotechnology2022
- 原文标识
- PubMed 34375187 · DOI 10.2174/1389201022666210810104226