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因嵌合抗原受体修饰 T (CAR-T) 细胞免疫治疗导致细胞因子释放综合征而使用免疫抑制剂后的 CMV 和 HSV 肺炎

英文原题:CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy.

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CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy.

PubMed 2021/11/01(内容时间) J Immunother Q3 · IF 2.9(JCR 2025)

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中文摘要

在预防措施尚未建立前,造血细胞移植后巨细胞病毒和单纯疱疹病毒1型(HSV-1)肺炎曾导致显著发病负担。嵌合抗原受体修饰T细胞免疫疗法后,疱疹病毒引起的终末器官疾病尚未得到充分描述。本文报告血液系统恶性肿瘤患者接受嵌合抗原受体修饰T细胞治疗后发生的病例:2例巨细胞病毒肺炎,以及1例HSV-1相关龈口炎、食管炎和肺炎。

展开英文摘要原文

Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy.

We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

论文信息

作者
Heldman MR、Ma J、Gauthier J、O'Hara RA、Cowan AJ、Yoke LM、So L、Gulleen E
单位
Division of Allergy and Infectious Diseases, Department of Medicine.
文献类型
病例报告 · 美国 NIH 资助研究
期刊
Journal of immunotherapy (Hagerstown, Md. : 1997)2021 Nov-Dec 01
原文标识
PubMed 34369454 · DOI 10.1097/CJI.0000000000000388