CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Bone marrow plasma level of decorin may be associated with improved treatment outcomes in a subset of multiple myeloma patients.
Bone marrow plasma level of decorin may be associated with improved treatment outcomes in a subset of multiple myeloma patients.
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我们的研究结果提示，核心蛋白聚糖可能在这一亚组 MM 患者中发挥保护作用。
采用酶联免疫吸附试验测定 270 例新诊断 MM（NDMM）患者骨髓血浆中的 decorin 水平。
按 decorin 水平将患者分为高组（H-DCN，>18.99 ng/mL）和低组（L-DCN，<9.76 ng/mL）。与低组相比，高组疾病分期更晚，骨溶解更明显，表现为 I 型胶原 C 端肽水平更高（0.69±0.55 对 0.49±0.36 ng/mL；P=0.028）。NDMM 患者骨髓血浆 decorin 与肝细胞生长因子（HGF）水平呈正相关（Pearson 相关系数 0.226；P<0.001）。与 decorin 较低（<12.95 ng/mL）的患者相比，HGF 较低（<0.79 ng/mL）但 decorin 较高（≥12.95 ng/mL）的患者治疗缓解率更高（90.5% 对 54.5%；P=0.015），总生存期也更长（中位数未达到，对 53 个月；P=0.0148）。多变量分析证实，在 HGF 低水平患者中，高 decorin 是治疗应答和生存的独立预测因素。
研究结果提示，decorin 可能对这一亚组 MM 患者发挥保护作用。
We measured decorin levels in BM plasma samples from 270 patients with newly diagnosed MM (NDMM) using enzyme-linked immunosorbent assays.
Patients were divided into high decorin (H-DCN, > 18.99 ng/mL) and low decorin (L-DCN <9.76 ng/mL) groups. Patients in the H-DCN group had more advanced-stage disease, including more osteolysis terms of higher levels of C-terminal telopeptides of type I collagen (0.69 0.55 vs. 0.49 0.36 ng/mL; P = 0.028), than those in the L-DCN group. Decorin levels correlated positively with hepatocyte growth factor (HGF) levels in BM plasma samples from NDMM patients (Pearson correlation coefficient, 0.226; P < 0.001). Patients with low HGF (<0.79 ng/mL) but high decorin levels ( 12.95 ng/mL) had a higher treatment response rate (90.5% vs. 54.5%, respectively; P = 0.015) and improved overall survival (not reached vs. 53 months; P = 0.0148) than those with lower decorin levels (<12.95 ng/mL). Multivariate analysis confirmed that a high decorin level was an independent predictive factor for treatment response and survival in patients with low HGF levels.
Our findings suggest that decorin may exert protective effects in this subset of MM patients.
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