RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
多形核髓源性抑制细胞的促肿瘤能力及其中和作用
英文原题：Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization.
查看英文原题
Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization.
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中文摘要
髓系衍生抑制细胞（MDSC）代表了一个高度免疫抑制的群体，在荷瘤宿主中扩增，并抑制T细胞和NK细胞的抗肿瘤效应功能。在MDSC亚群中，多形核（PMN）亚群正获得越来越多的关注，因为在大多数癌症实体中它是主要的MDSC亚群，并具有促进转移扩散的独特特性。此外，进一步改进PMN-MDSC与中性粒细胞的区分有助于设计新的治疗方法。在这篇综述中，我们总结了目前关于PMN-MDSC起源及其与经典中性粒细胞关系的观点。此外，我们概述了这些细胞的促转移特征以及靶向它们以提高癌症免疫疗法疗效的有前景的策略。
展开英文摘要原文
Myeloid-derived suppressor cells (MDSC) represent a highly immunosuppressive population that expands in tumor bearing hosts and inhibits both T and NK cell antitumor effector functions. Among MDSC subpopulations, the polymorphonuclear (PMN) one is gaining increasing interest since it is a predominant MDSC subset in most cancer entities and inherits unique properties to facilitate metastatic spread.
In addition, further improvement in distinguishing PMN-MDSC from neutrophils has contributed to the design of novel therapeutic approaches. In this review, we summarize the current view on the origin of PMN-MDSC and their relation to classical neutrophils.
Furthermore, we outline the metastasis promoting features of these cells and promising strategies of their targeting to improve the efficacy of cancer immunotherapy.
论文信息
- 作者
- Groth C、Weber R、Lasser S、Özbay FG、Kurzay A、Petrova V、Altevogt P、Utikal J
- 单位
- Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.Germany
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- International journal of cancer2021 Nov 1
- 原文标识
- PubMed 34224592 · DOI 10.1002/ijc.33731