CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
AML 中的免疫治疗：新兴策略简要综述
英文原题：Immunotherapy in AML: a brief review on emerging strategies.
查看英文原题
Immunotherapy in AML: a brief review on emerging strategies.
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中文摘要
急性髓系白血病（AML）是成人中最常见的白血病形式，也是最重要的血液系统恶性肿瘤之一。流行病学数据显示，其发病率高且生存率低，尤其是在成人继发性病例中。尽管经典和新型化疗方法已广泛改善了疾病预后和生存，但对更个性化、靶向特异性更强且副作用更少的方法的需求已不可避免。因此，免疫治疗方法具有重要意义。在以下综述中，首先简要介绍了该疾病的分子基础。其次，在介绍免疫治疗方法之前，讨论了AML与患者免疫系统之间错综复杂的关系。最后，涵盖了每种免疫治疗方法的作用机制和临床证据。
展开英文摘要原文
Acute myeloid leukemia (AML), the most common form of leukemia amongst adults, is one of the most important hematological malignancies. Epidemiological data show both high incidence rates and low survival rates, especially in secondary cases among adults. Although classic and novel chemotherapeutic approaches have extensively improved disease prognosis and survival, the need for more personalized and target-specific methods with less side effects have been inevitable.
Therefore, immunotherapeutic methods are of importance. In the following review, primarily a brief understanding of the molecular basis of the disease has been represented. Second, prior to the introduction of immunotherapeutic approaches, the entangled relationship of AML and patient's immune system has been discussed. At last, mechanistic and clinical evidence of each of the immunotherapy approaches have been covered.
论文信息
- 作者
- Moeinafshar A、Hemmati S、Rezaei N
- 第一作者单位
- Cancer Immunology Project Interest Group (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.Iran
- 通讯作者单位
- Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. rezaei_nima@yahoo.com.Iran
- 文献类型
- 综述
- 期刊
- Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021 Dec
- 原文标识
- PubMed 34160771 · DOI 10.1007/s12094-021-02662-1