CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CD19 "CAR"-T 细胞治疗儿童及青年 B 细胞急性淋巴细胞白血病的操作手册
英文原题：An owner's manual for CD19 "CAR"-T cell therapy in managing pediatric and young adult B-cell acute lymphoblastic leukemia.
查看英文原题
An owner's manual for CD19 "CAR"-T cell therapy in managing pediatric and young adult B-cell acute lymphoblastic leukemia.
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中文摘要
新诊断 B 细胞急性淋巴细胞白血病（B-ALL）患者虽有很高治愈率，但仍需改善儿童复发或难治（r/r）B-ALL 的治疗结局。嵌合抗原受体（CAR）T 细胞疗法已在 26 岁以下 r/r B-ALL 儿童、青少年和青年患者中显示持久应答，安全性可管理，其中包括异基因干细胞移植后复发的患者。本综述全面总结 CAR-T 治疗儿童及青年 r/r B-ALL 的现有数据、管理实践和未来方向，内容包括患者筛选、治疗准备及 CAR-T 输注，以及短期和长期安全事件的监测与处理、长期监测和生存者管理。临床试验注册号：不适用。
展开英文摘要原文
Despite excellent cure rates in newly diagnosed patients with B-cell acute lymphoblastic leukemia (B-ALL), therapies that improve outcomes for children with relapsed or refractory (r/r) B-ALL are needed. Chimeric antigen receptor (CAR)-T cell therapy has demonstrated durable responses and a manageable safety profile in children, adolescents, and young adults less than 26 years old with r/r B-ALL, including patients who have relapsed after allogeneic stem cell transplant.
This comprehensive review summarizes current data, management practices, and future directions for the treatment of r/r B-ALL in pediatric and young adult patients with CAR-T cell therapy, including patient selection, patient preparation, and CAR-T cell infusion, as well as monitoring and management of short- and long-term safety events, long-term surveillance, and survivorship. Clinical trials registration number: N/A.
论文信息
- 作者
- Laetsch TW、Yanik GA、Boyer MW、Rheingold SR
- 第一作者单位
- Division of Oncology and Cellular Therapy, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3501 Civic Center Blvd, CTRB 4016 (TWL), ARC 1420 (SRR), Philadelphia, PA 19104, USA. Electronic address: laetscht@chop.edu.United States
- 通讯作者单位
- Division of Oncology and Cellular Therapy, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3501 Civic Center Blvd, CTRB 4016 (TWL), ARC 1420 (SRR), Philadelphia, PA 19104, USA. Electronic address: rheingold@chop.edu.United States
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- Blood reviews2021 Nov
- 原文标识
- PubMed 33994222 · DOI 10.1016/j.blre.2021.100848