单细胞解析揭示 CD5 或 CD7 靶向 CAR-T 细胞治疗后的免疫失调
Single-Cell Dissection Reveals Immune Dysregulation After CD5 or CD7-Directed Chimeric Antigen Receptor T-Cell Therapy.
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FOR TREATMENT
现在就能报名的(招募中)排在最前,共 1 项。同一状态内中国中心优先。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Single-Cell Dissection Reveals Immune Dysregulation After CD5 or CD7-Directed Chimeric Antigen Receptor T-Cell Therapy.
Translational development and first-in-human compassionate infusion of NK-92 cells expressing a CD5-based chimeric antigen receptor (SRCD5CAR-NK-92) i
尽管患者最终因基础血液系统恶性肿瘤进展而死亡,但这是 SRCD5CAR-NK-92 细胞在严重 MDR IFI 背景下的首次人体使用。结果凸显了其作为一种安全、现货型治疗策略的潜力,同时强调需要进一步研究其疗效和长期结局。
IL-7Rα signaling potentiates the anti-tumor activity of NK92 cells.
IL-7R-IM 的表达赋予 NK 和 CAR-NK 细胞细胞因子非依赖性以及强效的抗肿瘤活性。该策略为提高用于临床应用的现货型 NK 细胞疗法的持久性与疗效提供了一种切实可行的解决方案。
A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo.
Blast phase of chronic myeloid leukemia presenting as early T-cell precursor acute lymphoblastic leukemia.
CML-BP 患者可能伴有 ETP-ALL。这些患者通常临床病程侵袭性强,需要强化治疗,并可能从干细胞移植中获益。
Comparison of the blood immune repertoire with clinical features in chronic lymphocytic leukemia patients treated with chemoimmunotherapy or ibrutinib
Establishment and comprehensive analysis of a new human cell line (NK-NJ) with NK-cell characteristics established from extranodal natural killer cell
Increased Activity of a NK-Specific CAR-NK Framework Targeting CD3 and CD5 for T-Cell Leukemias.
The Role of Changes in the Redox Status in the Pathogenesis of Chronic Lymphocytic Leukemia.
Tuberculosis-induced aplastic crisis and atypical lymphocyte expansion in advanced myelodysplastic syndrome: A case report and review of literature.
播散性结核可诱导骨髓中 CD56+淋巴细胞浸润,进而抑制正常和白血病性造血,导致再生障碍性危象和白血病细胞消退。
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