下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Advances in CAR-T therapy for central nervous system tumors.
CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展;
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial.
主要终点为 tebotelimab 单药给药(n = 269)或与抗 HER2 抗体 margetuximab 联合给药(n = 84)时的安全性和最大耐受剂量。
A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer.
CD19特异性CAR T细胞治疗白血病/淋巴瘤的疗效,至少部分依赖于特定CAR的独特性质以及健康B细胞的存在,后者通过反复刺激增强靶细胞裂解和细胞因子分泌。
Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment.
使用嵌合抗原受体(CAR)T 细胞治疗 B 细胞淋巴瘤和白血病已取得显著成功。
CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Recept
我们得出结论,CAR的分子结构、膜组织和流动性是关键的设计参数,能够预测有效免疫突触的形成。
Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy.
用嵌合Ag受体(CAR)工程化免疫细胞是癌症免疫治疗中一项有前景的技术。
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs.
肿瘤免疫治疗对改善肿瘤患者的预后有显著贡献。
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy.
嵌合抗原受体(CAR)T细胞疗法已成为一种开创性的癌症治疗方法,在治疗某些血液系统恶性肿瘤如淋巴瘤和白血病方面取得了前所未有的成功。
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