下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Arlocabtagene autoleucel: a GPRC5D-targeted CAR T-cell therapy for heavily pretreated relapsed/refractory multiple myeloma.
患者(N = 84)中位接受过 5 线既往治疗,49% 既往接受过 B 细胞成熟抗原靶向治疗。
Anti-BCMA/GPRC5D CAR T cells in patients with relapsed or refractory multiple myeloma who have extraosseous extramedullary disease.
这些发现支持抗 BCMA/GPRC5D 双特异性 CAR T 细胞在伴骨外 EMD 的复发/难治性多发性骨髓瘤(RRMM)患者中诱导了高缓解率,且安全性可控。
How I treat plasma cell leukemia.
浆细胞白血病(PCL)是一种极具侵袭性的浆细胞恶性肿瘤,根据国际骨髓瘤工作组共识,其定义为外周血中循环浆细胞≥5%,且患者在其他方面符合多发性骨髓瘤(MM)的诊断标准。
Subsequent CAR-T and engineered antibody for relapsed/refractory multiple myeloma following BCMA-targeted treatment: a systematic review and meta-anal
GPRC5D CAR-T 在 BCMA 治疗后场景中显示出优于工程化抗体的疗效。
Concurrent administration of BCMA and GPRC5D chimeric antigen receptor (CAR) T cells in advanced multiple myeloma.
我们在 3 个剂量水平治疗了 15 例患者;其中包括 6 例接受 MCARH125 单药治疗的患者和 9 例接受 MCARH125 与 MCARH109 同时输注的患者。
Real-world evidence on infection risk in multiple myeloma treated with BiTEs and CAR-T cells: a meta-analysis.
在真实世界实践中,接受 T 细胞重定向治疗的 RRMM 患者中约每 4 例就有 1 例发生严重感染。
Incorporating the Next Generation of Immunotherapies Into the Treatment of Multiple Myeloma.
免疫治疗近期改变了多发性骨髓瘤(MM)的治疗格局。
Dual-antigen-targeting T-cell immunotherapies in MM: circumventing tumor heterogeneity and preventing antigen escape.
双靶向最终应在大规模 III 期试验中,与靶点转换的单靶向药物序贯治疗这一经典方案进行比较。
B-cell maturation antigen-targeted CAR T cell as a salvage therapy for progressive multiple myeloma after anti-G proteincoupled receptor, class C grou
抗BCMA CAR T细胞疗法对anti-GPRC5D CAR T细胞疗法治疗失败后的RRMM有效,且安全性可接受。
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