靶向头颈部鳞状细胞癌中的 NKG2D 轴:从分子机制到临床应用
Targeting the NKG2D axis in head and neck squamous cell carcinoma: from molecular insights to clinical applications.
头颈部鳞状细胞癌(HNSCC)是一种侵袭性癌症,其通过损害自然杀伤(NK)细胞和细胞毒性 T 淋巴细胞上的 NKG2D 受体来逃避免疫监视。
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Targeting the NKG2D axis in head and neck squamous cell carcinoma: from molecular insights to clinical applications.
头颈部鳞状细胞癌(HNSCC)是一种侵袭性癌症,其通过损害自然杀伤(NK)细胞和细胞毒性 T 淋巴细胞上的 NKG2D 受体来逃避免疫监视。
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma.
头颈部鳞状细胞癌(HNSCC)仍是最具侵袭性的恶性肿瘤之一,治疗选择有限,尤其是在复发和转移性病例中。
PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors.
CD4+ Th细胞在协调免疫反应中发挥关键作用,但参与抗肿瘤免疫反应的CD4+ Th细胞的身份仍有待确定。
Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC.
在此,我们整合了两个单细胞RNA测序(scRNA-seq)数据集,来自29个样本,总计近300,000个免疫细胞,以解析HPV阴性HNSCC肿瘤进展和淋巴结转移过程中的免疫重塑。
Unraveling the Role of Tumor-Infiltrating Immune Cells in Head and Neck Squamous Cell Carcinoma: Implications for Antitumor Immune Responses and Immun
头颈部鳞状细胞癌(HNSCC)是一种高度异质性的恶性肿瘤,其特征是复杂的肿瘤微环境(TME),在疾病进展和治疗耐药中起关键作用。
Buparlisib and Paclitaxel in Patients with Head and Neck Squamous Cell Carcinoma: Immunogenomic Biomarkers of Efficacy from the BERIL-1 Study.
在这项BERIL-1的免疫基因组分析中,观察到在肿瘤免疫浸润和特定致癌改变(包括PIK3和NOTCH通路激活)的患者中,OS的HR有所改善(NCT01852292)。
The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy.
手术、放疗和/或化疗是标准治疗,但 5 年总生存期不足 50%。
Exploring the potential of CAR-NK cell therapy in the management of head and neck cancer (HNC): a narrative review.
CAR-NK 细胞通过将靶向细胞毒作用与更优的安全性特征相结合,为 HNSCC 提供了新的治疗途径。
The Single-Cell Landscape of Peripheral and Tumor-infiltrating Immune Cells in HPV- HNSCC.
在此,我们整合了两个单细胞RNA测序数据集,涵盖29个样本和近300,000个免疫细胞,以探究肿瘤进展和淋巴结转移过程中的免疫细胞动态。
The dynamic role of immune checkpoint molecules in diagnosis, prognosis, and treatment of head and neck cancers.
然而,在复发或转移性HNSCC中,免疫治疗的总体缓解率在14-32%之间,临床缓解和治疗成功难以预测。
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