分泌抗 CD73 scFv 的增强型 CD33 CAR-NK 细胞克服腺苷介导的免疫抑制并提高抗 AML 疗效
Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.
CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境,展现出更优的抗白血病疗效。
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Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.
CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境,展现出更优的抗白血病疗效。
CAR-Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune-Mediated Inflammation.
嵌合抗原受体(CAR)工程化细胞疗法正从血液系统恶性肿瘤拓展至自身免疫性、炎症性和纤维化疾病,尽管各平台和适应证的证据成熟度差异显著。
Depletion of an immature cord blood NK subset reverses trogocytosis-driven CAR NK dysfunction.
这些发现定义了供者亚群驱动的CAR NK功能障碍机制,并提供了一种提高抗肿瘤效力的生产策略。
Circumventing Ewing sarcoma tumor microenvironment resistance by IL1RAP CAR-modified TGFβ1-imprinted natural killer cells in combination with IL-15 ag
我们的临床前数据表明,利用靶向肿瘤的TGFβ1印记IL1RAP-CAR-NK细胞,联合IL-15激动剂和抗GD2抗体所进行的组合性先天免疫治疗,是一种有前景的针对转移性/复发性/难治性ES的新型治疗策略。
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.
全球癌症负担日益加重,亟需创新的治疗策略。
Ultrasensitive In Vivo Imaging of Adoptive Immune Cell Distribution and Expansion Using Second Near-Infrared Conjugated Oligoelectrolyte Probes.
监测实体瘤中的过继性细胞治疗对于评估疗效和指导临床用药至关重要,但现有技术灵敏度差、背景信号高且会干扰治疗功能,使监测受到制约。
Advancing CAR-NK cell therapy in solid tumors: Current landscape and future directions.
嵌合抗原受体(CAR)工程化的自然杀伤(NK)细胞已成为一种有前景的现代免疫治疗策略,相较于CAR-T细胞疗法,其具有先天细胞毒性、安全性特征以及可规模化、现货型异体制造的潜力等优势。
Exploring CAR cell therapies beyond CAR-T for myeloid malignancies.
嵌合抗原受体(CAR)-T细胞在多种血液系统恶性肿瘤中已展现出显著疗效;
Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian
这是一项 I/II 期注册临床试验,评估 CAR-NK 细胞治疗胰腺癌、卵巢癌的安全性、可行性及初步疗效。当前状态:进行中(不再招募)。计划入组 51 例。试验地点:美国 · 休斯顿(共 1 个中心)。登记号:NCT05922930。
Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.
同时靶向 PD-L1 与 ErbB2 可通过对抗原异质性提供抵抗力并经协同激活放大抗肿瘤信号,增强 CAR-NK 细胞对难治性实体瘤的疗效。
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