CELL INTELLIGENCE · 肿瘤细胞治疗研究

自协同 RNA 疫苗减轻树突状细胞介导的获得性免疫抵抗以增强细胞疗法对实体瘤的疗效

Self-Cooperative RNA Vaccine Mitigates Dendritic Cell-Mediated Acquired Immune Resistance to Potentiate Cell Therapy for Solid Tumors.

定制的 HER2 ECD mRNA-LNP 疫苗增强 CD8(+) T 细胞介导的抗肿瘤免疫以抑制 HER2 阳性肿瘤

Tailored HER2 ECD mRNA-LNP vaccines boost CD8(+) T cell-mediated antitumor immunity for HER2-positive tumor suppression.

局部水凝胶递送光激活 mRNA 脂质纳米颗粒与透明质酸酶用于术后 TNBC 免疫治疗

Localized hydrogel delivery of photoactivatable mRNA lipid nanoparticles and hyaluronidase for postoperative TNBC immunotherapy.

mRNA 脂质纳米颗粒介导的线粒体凋亡增强过继性 T 细胞免疫疗法

mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy.

通过红细胞介导的 mRNA 递送在体内生成 CAR 髓系细胞用于癌症免疫治疗

In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy.

通过 mRNA-LNP 工程化 CLL-1 CAR-NK 细胞以获得强效抗肿瘤活性并逆转急性髓系白血病中 HLA-E 介导的耐药

Engineering CLL-1 CAR-NK cells via mRNA-LNP for potent antitumor activity and reversal of HLA-E-mediated resistance in acute myeloid leukemia.

瞬时、非整合的 mRNA LNP 转染的 CLL-1 CAR-NK 细胞为 MDR AML 提供了一种安全有效的策略。

经香茅醇定制的 mRNA-tLNPs 实现更优的 T 细胞工程体内疗效

Superior In Vivo Efficacy for T Cell Engineering via Citronellol-Tailored mRNA-tLNPs.

结构优化的 HPV16 E7/E6 mRNA-LPP 通过肿瘤微环境重编程介导剂量节约效应

Structurally-optimised HPV16 E7/E6 mRNA-LPP mediates dose-sparing efficacy via tumour microenvironment reprogramming.

氟化脂质纳米颗粒实现实体瘤体内 CAR-巨噬细胞治疗并增强抗 PD-L1 免疫治疗

Fluorinated lipid nanoparticles enable in vivo CAR-macrophage therapy in solid tumor and enhance anti PD-L1 immunotherapy.

基于器官囊过滤的胰腺靶向脂质纳米颗粒

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration.