下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
FRONTIER PAPERS
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.
结直肠癌(CRC)的治疗格局随着分子亚型的识别而不断演变,这些亚型包括错配修复缺陷/微卫星高度不稳定、POLE突变、RAS/BRAF改变以及HER2扩增,使得精准治疗和免疫检查点抑制剂可用于特定人群。
Current and Emerging Targeted Therapy in Advanced Gastroesophageal Adenocarcinoma.
背景/目的:晚期胃食管腺癌(GEA)预后较差,尽管采用标准化疗,中位总生存期仍为13-20个月。
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.
胶质母细胞瘤(GB)仍是治疗抵抗性最强的实体瘤之一,其特征是显著的代谢可塑性、瘤内异质性和高度免疫抑制的微环境。
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma.
头颈部鳞状细胞癌(HNSCC)仍是最具侵袭性的恶性肿瘤之一,治疗选择有限,尤其是在复发和转移性病例中。
Chimeric antigen receptor NK cells for breast cancer immunotherapy.
乳腺癌是全球女性中最常见的恶性肿瘤,需要超越手术、化疗、放疗和内分泌治疗等传统疗法的创新治疗策略。
The impact of the immunological context on outcomes of solid cancer patients treated with genotype-matched targeted therapies: a comprehensive review.
据我们所知,这是首个评估免疫学背景作为靶向治疗生物标志物的综述。本综述的结果为未来转化研究推进分层精准肿瘤医学提供了重要资源。
CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials.
胶质母细胞瘤(GBM)是一种侵袭性原发性脑肿瘤,预后不良,有效治疗方案很少。
Therapeutic advances in the targeting of ROR1 in hematological cancers.
受体酪氨酸激酶(RTK)是参与细胞通讯和信号转导的关键细胞表面受体,在细胞生长、分化、存活和代谢中极为重要。
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