肿瘤细胞治疗研究
FRONTIER PAPERS
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.
NR4A 因子通过线粒体基因表达调控 CAR-T 细胞的持久性和干性，因此 NR4A 是生成针对实体瘤的优质 CAR-T 细胞的高度有前景的靶点。
Human Epidermal Growth Factor Receptor 2 Positive Advanced Gastric or Esophagogastric Adenocarcinoma: Reflecting on the Past to Gain a New Insights.
曲妥珠单抗作为 HER2 阳性 AGC 的标准治疗已长达十年，随后，抗体偶联药物（ADC）德曲妥珠单抗问世，并展现出令人瞩目的缓解。
A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cel
抗 CD19 嵌合抗原受体（CAR）T 细胞疗法治疗难治性 B 细胞恶性肿瘤显示出优异的治疗效果。
Pharmacotherapy for previously treated gastric cancer patients: current options and future developments.
生物标志物驱动的治疗有望在未来成为主流方法。
Mechanisms of resistance to antibody-drug conjugates in cancers.
近年来，随着分子靶向药物、单克隆抗体、免疫检查点抑制剂、双特异性抗体和 CAR-T 细胞疗法等多种治疗模式的出现，癌症治疗取得了巨大进展。
Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma.
据我们所知，这是首个表明 HER2 靶向 CAR-T 细胞对分子学定义的滑膜肉瘤细胞具有直接效果的研究。
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