靶向 ICAM1 的共刺激通过与 TCR 信号协同将 HER2 CAR T 细胞毒性扩展至 HER2 低表达和 HER2 阴性肿瘤
ICAM1-targeted costimulation extends HER2 CAR T cytotoxicity to HER2-low and HER2-negative tumors through synergy with TCR signaling.
自体T细胞经工程化表达HER2嵌合抗原受体(CAR)后,临床疗效有限。
FRONTIER PAPERS
ICAM1-targeted costimulation extends HER2 CAR T cytotoxicity to HER2-low and HER2-negative tumors through synergy with TCR signaling.
自体T细胞经工程化表达HER2嵌合抗原受体(CAR)后,临床疗效有限。
Antigen-induced IL-12 potentiates piggyBac-engineered HER2-CAR-T cells against gastric cancer.
胃癌(GC)通常无症状进展,导致确诊时已处于晚期,治疗选择有限,因此迫切需要更有效的治疗方法。
Fighting HER2 in Gastric Cancer: Current Approaches and Future Landscapes.
胃癌(GC)仍是全球癌症相关死亡的主要原因,其中人表皮生长因子受体2(HER2)阳性疾病代表了一个具有临床相关性的亚群。
Challenges and perspectives of CAR-T cell therapy in solid tumours: insights from gastric cancer.
胃癌(GC)仍然是一项重大挑战,因为它是全球最常见且最致命的恶性肿瘤之一。
HER2-positive gastric cancer: from targeted therapy to CAR-T cell therapy.
胃癌(GC)在全球范围内的发病率位居第五,其中 HER2 阳性胃癌是一个具有更复杂生物学特征的独特亚型。
A literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies.
免疫治疗通过改善生存期和生活质量,正在重塑胃癌的管理格局。持续的研究和临床评估对于优化个性化及有效治疗方案至关重要。
Human Epidermal Growth Factor Receptor 2 Positive Advanced Gastric or Esophagogastric Adenocarcinoma: Reflecting on the Past to Gain a New Insights.
曲妥珠单抗作为 HER2 阳性 AGC 的标准治疗已长达十年,随后,抗体偶联药物(ADC)德曲妥珠单抗问世,并展现出令人瞩目的缓解。
HER2(+) advanced gastric cancer: Current state and opportunities (Review).
人表皮生长因子受体2(HER2)阳性胃癌(GC)是GC的一种独特亚型,占所有GC病例的10-20%。
Antibody-Mediated Therapy in Gastric Cancer: Past, Present, and Future.
在胃癌治疗中,细胞毒性化疗的疗效有限,这在很大程度上由深刻的分子与生物学异质性所驱动。
HER2 as a molecular trojan horse in prostate cancer: mechanistic insights and therapeutic unlocks.
人表皮生长因子受体 2(HER2/ERBB2)是乳腺癌和胃癌中已确立的治疗靶点,但其在前列腺癌(PC)中的意义仍未明确。
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