CELL INTELLIGENCE · 肿瘤细胞治疗研究

下一代基于抗体的癌症治疗：抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用

Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors

短程递增给药 glofitamab 使弥漫大 B 细胞淋巴瘤患者抗 CD19 CAR-T 细胞治疗失败后死亡风险减半：LYSA BiCAR 预设外部对照臂 II 期试验最终结果

Short ramp-up glofitamab halves mortality risk after anti-CD19 CAR T-cell therapy failure in patients with diffuse large B-cell lymphoma: final result

复发/难治性 B 细胞非霍奇金淋巴瘤中 CD19/20 CAR-T 疗法的临床结局与空间转录组图谱

Clinical outcomes and spatial transcriptomic profiles of CD19/20 CAR-T therapy in relapsed or refractory B-cell non-Hodgkin's lymphoma.

双特异性 CD19/20 CAR-T 疗法产生了持久的临床活性，且毒性可控。

构建一种高度通用、经优化的 TCR 双特异性支架，用于靶向肿瘤特异性肽-HLA 抗原

Generation of a highly versatile TCR bispecific scaffold optimized for targeting tumor-specific peptide-HLA antigens.

AI 引导的 CAR 设计与靶向通路调控以增强多抗原 CAR-T 细胞持久性并克服抗原逃逸

AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape.

系统综述与荟萃分析：CAR-T 对比双特异性抗体作为滤泡性淋巴瘤三线及后线治疗

Systematic review and meta-analysis: CAR-T vs bispecific antibody as third or later-line therapy for follicular lymphoma.

疗效-安全性权衡与患者选择：一项为 R/R B-NHL 中 CAR-T 与双特异性抗体临床选择提供依据的 meta 分析

Efficacy-safety trade-off and patient selection: a meta-analysis informing clinical choice between CAR-T and bispecific antibodies for R/R B-NHL.

接头 CAR 共表达在淋巴瘤单一及双重抗原丢失后保留 CAR-T 细胞疗效

Co-expression of an adapter CAR retains efficacy of CAR T cells after single and dual antigen loss in lymphoma.

成人急性淋巴细胞白血病的治疗：综述

Management of Adult Acute Lymphoblastic Leukemia: A Review.

ALL 的治疗正在迅速变化。研究者已经评估了一线及后线方案，采用酪氨酸激酶抑制剂与免疫治疗的联合方案，化疗强度更低或不再使用化疗。未来研究将评估 CD19、CD20 和 CD22 多靶点抗体及 CAR-T 细胞疗法、新型抗体制剂，以及强度更低/疗程更短的方案。

DLBCL 整合基因组分析鉴定与双特异性抗体应答相关的免疫环境

Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response.