CELL INTELLIGENCE · 肿瘤细胞治疗研究

靶向 CD79b 的三种新型 CAR 用于非霍奇金淋巴瘤治疗的临床前开发及靶抗原丢失特征分析

Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin's lymphoma and characterization of the loss of the target

基于特异性、疗效和靶抗原丢失，CARLY3 代表了一种针对非霍奇金淋巴瘤的潜在新型 CAR 治疗。

ARI0003：共转导 CD19/BCMA 双靶向 CAR-T 细胞治疗非霍奇金淋巴瘤

ARI0003: Co-transduced CD19/BCMA dual-targeting CAR-T cells for the treatment of non-Hodgkin lymphoma.

CD19 CAR-T 疗法在复发/难治性非霍奇金淋巴瘤（NHL）中已取得显著缓解。

CAR 与嵌合共刺激受体联用增强 T 细胞对低抗原密度的敏感性并促进持久性

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence.

尽管使用针对血液系统恶性肿瘤的CAR-T细胞取得了高缓解率，仍有相当比例的患者最终出现肿瘤复发。