CELL INTELLIGENCE · 肿瘤细胞治疗研究

下一代基于抗体的癌症治疗：抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用

Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors

CD19 与 BCMA 靶向 CAR-T 细胞治疗中输注前宿主骨髓易感性：克隆性造血、血液毒性与治疗相关髓系肿瘤

Pre-Infusion Host-Marrow Vulnerability in CD19- and BCMA-Directed CAR T-Cell Therapy: Clonal Hematopoiesis, Hematotoxicity, and Therapy-Related Myeloi

BCMA/CD19 双靶向 CAR-T 细胞疗法用于新诊断多发性骨髓瘤老年患者：一项 1 期研究

BCMA/CD19 dual-targeting CAR T-cell therapy in older patients with newly diagnosed multiple myeloma: a phase 1 study.

将 B 细胞与浆细胞靶向从肿瘤学转化至自身免疫：模式、定量桥接与开发路线图

Translating B-Cell and Plasma-Cell Targeting from Oncology to Autoimmunity: Modalities, Quantitative Bridging, and a Development Roadmap.

CXCR4 修饰通过改善 B 细胞恶性肿瘤的肿瘤追踪与骨髓归巢增强 CAR-T 疗效

CXCR4-modification enhances CAR-T efficacy by improving tumor tracking and bone marrow homing in B-cell malignancies.

早期鞘内注射地塞米松和甲氨蝶呤作为 CAR-T 细胞治疗后免疫效应细胞相关神经毒性综合征的有效方法

Early intrathecal dexamethasone and methotrexate as an effective approach for immune effector cell-associated neurotoxicity syndrome after CAR-T cell

我们的数据提示，早期给予 IDM 可能有助于快速缓解 CAR-T 细胞治疗后的重度或类固醇难治性 ICANS，这可能为这些患者的后续治疗创造机会。

验证 BCMA-CD19 复合 CAR-T 疗法在 SLE 重叠综合征中的疗效：超过 1.5 年随访

Validation of BCMA-CD19 Compound CAR-T Therapy in SLE Overlap Syndrome: Over 1.5-Year Follow-Up.

cCAR 疗法有效清除致病细胞群，是治疗难治性 SLE 及相关 AID 的一种有前景的转化策略。

复发/难治性多发性骨髓瘤患者 CAR-T 治疗后继发治疗相关急性髓系白血病且预后不良

Therapy related acute myeloid leukemia secondary to CAR-T therapy in refractory/relapsed multiple myeloma patient showing poor prognosis.

BCMA CAR-T 治疗作为浆母细胞性骨髓瘤患者的挽救治疗

BCMA CAR-T therapy as salvage therapy in patients with plasmablastic myeloma.

BCMA CAR-T 疗法作为 PBM 的挽救治疗安全有效，且其毒性可控。

揭示多发性骨髓瘤中因果免疫细胞-基因关联：系统综述与孟德尔随机化分析的启示

Unveiling causal immune cell-gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses.

我们的研究支持 CAR-T 细胞疗法在 rrMM 患者中的疗效和安全性，ORR 为 82.2%，严重 CRS（6.3%）和神经毒性（0.9%）发生率低。这一发现还提示 BCMA/CD19 双特异性 CAR-T 细胞具有更优的 ORR，尚待临床确认。MR 分析揭示了免疫细胞、VDR 和 VHL 等基因与 MM 之间的关联，增进了我们对其病理生理学的理解。