肿瘤免疫治疗中的 T 细胞耗竭:异质性、机制与治疗机遇
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.
T 细胞耗竭是癌症免疫逃逸的关键机制,其固有的异质性和动态可塑性是免疫检查点抑制剂(ICI)应答差异和耐药的关键决定因素。
FRONTIER PAPERS
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.
T 细胞耗竭是癌症免疫逃逸的关键机制,其固有的异质性和动态可塑性是免疫检查点抑制剂(ICI)应答差异和耐药的关键决定因素。
Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T.
我们的发现表明,OVV-01 不仅具有强效的直接溶瘤活性,还通过改善抗原呈递和 T 细胞活化来增强过继 T 细胞治疗的疗效。
Innovative immunotherapeutic strategies for thyroid cancer: challenges and opportunities.
甲状腺癌是全球第七大常见癌症,发病率和死亡率不断上升。
Igniting Cold Tumors: Multi-Omics-Driven Strategies to Overcome Immune Evasion and Restore Immune Surveillance.
冷肿瘤,以免疫细胞浸润不足和高度免疫抑制的肿瘤微环境(TME)为特征,对常规免疫治疗表现出有限的响应性。
Application of oncolytic virus in tumor therapy.
溶瘤病毒(OVs)能选择性杀伤肿瘤细胞而不影响正常细胞,同时激活患者的固有免疫和适应性免疫系统。
Viral oncogenesis and immune remodeling: Decoding the therapeutic potential of immune checkpoint inhibitors in virus-associated cancers.
多种病毒被广泛认为是众多血液系统恶性肿瘤和实体瘤发生的关键因素。
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