肿瘤细胞治疗研究
FRONTIER PAPERS
近 5 年肿瘤细胞治疗领域的研究论文。默认按评分排序(权威性 + 新鲜度)。
AI-driven radiomics and radiogenomics: supporting the assessment and differentiation of pseudoprogression in cellular immunotherapy for glioblastoma.
CAR-T Cell Therapy for Glioblastoma: Obstacles and Advances.
Correction: Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma.
Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial.
NF-κB/NFAT signaling contributes to B7-H3 TRuC-T cell cytotoxicity and supports a reporter platform for glioblastoma immunotherapy.
在与 B7-H3 结合后,NFAT 和 NF-κB 信号通路均被激活,并参与调控靶向 B7-H3 的 TRuC-T 细胞。我们的数据表明,整合到这些 TRuC 构建体中的 NF-κB/NFAT 转录报告基因可用于监测靶标识别,并可能作为细胞毒性疗效的早期指标。总体而言,该系统提示了 GBM 治疗的一条潜在途径,并为 TRuC-T 细胞治疗效力的功能评估提供了初步框架。
Combinatorial therapy with resveratrol sensitizes glioblastoma to NKG2D CAR-T cells.
Dual-modular-nanobody CAR-T cell technical platform against the solid tumor microenvironment.
FAP/CTLA-4 DMN CAR-T 通过局部免疫调节克服免疫抑制性实体瘤微环境,在临床前模型和一例难治性胶质母细胞瘤患者中显示出有前景的疗效。
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