CELL INTELLIGENCE · 肿瘤细胞治疗研究

通过脂质辅助聚合物纳米颗粒工程化干扰素-γ增强型嵌合抗原受体巨噬细胞用于癌症免疫治疗

Engineering Interferon-γ-Enhanced Chimeric Antigen Receptor Macrophages via Lipid-Assisted Polymeric Nanoparticles for Cancer Immunotherapy.

目的 To develop an efficient strategy for in vivo engineering of M1-like CAR-Ms for cancer therapy. 方法 We designed a lentiviral vector encoding a CAR targeting BCMA and a cytokine cassette. Macrophages were transduced and

CAR-T 疗法治疗中枢神经系统肿瘤的进展

Advances in CAR-T therapy for central nervous system tumors.

CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展；

Bcl-2 修饰的嵌合抗原受体对增强实体瘤靶向的协同效应

Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting.

我们的研究结果表明，将抗凋亡分子整合到CART细胞中可能增强其对抗实体瘤的治疗效果。