PARP 抑制剂联合安罗替尼作为卵巢癌装甲 CAR-T 细胞的桥接治疗可增强浸润与抗肿瘤疗效
PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR-T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy.
肿瘤细胞治疗研究
FRONTIER PAPERS
近 5 年肿瘤细胞治疗领域的研究论文。默认按评分排序(权威性 + 新鲜度)。
PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR-T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy.
Combined targeting of mesothelin and tenascin-C enhances CAR-T cell function and tumor microenvironment modulation in ovarian cancer.
在卵巢癌模型中,联合靶向 MSLN 和 TNC 与 CAR-T 细胞活化改善及更广泛的微环境重塑相关。
The Role of Mesothelin in Gynecological Tumors and Its Significance in Targeted Therapies-A Review.
Asiaticoside enhances the antitumor efficacy of MSLN-targeted CAR-T cells in ovarian cancer.
我们的研究结果表明,AC 可减轻 CAR-T 细胞耗竭,并对抗 TGF- 介导的免疫抑制。AC 是一种有前景、可临床转化的药理学佐剂,用于克服 CAR-T 细胞疗法在实体瘤中的瓶颈。
T-cell receptor-like chimeric antigen receptor T cells targeting mesothelin: A first-in-human dose-escalation trial for platinum-resistant advanced ov
本研究提示,KT127 具有可控的安全性特征,并在晚期卵巢癌患者中显示出初步的生物学活性,尤其是那些多线治疗失败的患者。
Advancements in CAR-T Cell Therapy for Ovarian Cancer: Current Strategies and Future Directions.
Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.
Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations.
这些数据建立了工程化逻辑门控单载体免疫疗法的框架,并提供了生成携带超出当前尺寸限制转基因的 CAR-T 细胞的优化工作流程。
Current Developments of CAR-T and CAR-NK Cell Therapies for Ovarian Cancer.
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