低剂量多西他赛重编程 CAR T 细胞以增强实体瘤免疫
Low-dose docetaxel reprograms CAR T cells for enhanced solid tumor immunity.
这些发现描述了一种非遗传药理学预激活策略,具有潜在的可扩展性并与现有生产工艺兼容。该方法在临床前模型中展示了增强的CAR T细胞对抗实体瘤屏障的性能,突显了化疗-免疫治疗协同作用的潜力。
FRONTIER PAPERS
Low-dose docetaxel reprograms CAR T cells for enhanced solid tumor immunity.
这些发现描述了一种非遗传药理学预激活策略,具有潜在的可扩展性并与现有生产工艺兼容。该方法在临床前模型中展示了增强的CAR T细胞对抗实体瘤屏障的性能,突显了化疗-免疫治疗协同作用的潜力。
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
Immune Checkpoint Blockade and Emerging Combination Platforms in Breast Cancer: A Narrative Review.
这篇叙述性综述探讨了乳腺癌(BC)免疫治疗的最新进展,重点关注免疫检查点抑制剂(ICI)单药及与其他治疗方式的联合应用。
Applications of mRNA Delivery in Cancer Immunotherapy.
癌症治疗不断进步,免疫治疗作为一种标准模式日益突出,已显著改善多种恶性肿瘤的治疗。
CAR-based immunotherapy for breast cancer: peculiarities, ongoing investigations, and future strategies.
手术、化疗和内分泌治疗改善了Luminal A型、Luminal B型和HER2阳性乳腺癌的总生存率和术后复发率,但预后较差的三阴性乳腺癌(TNBC)的治疗方式仍然有限。
Facts and prospects of peptide in targeted therapy and immune regulation against triple-negative breast cancer.
三阴性乳腺癌(TNBC)是乳腺癌中最具侵袭性的亚型。
Emerging Targeted and Multimodal Therapeutic Strategies in Breast Cancer: A Comprehensive Review.
这些发现表明,乳腺癌治疗的未来将依赖于针对每个肿瘤和每位患者独特生物学特性设计的个性化、多靶点策略。
AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery.
三阴性乳腺癌(TNBC)的定义是高度异质性、休眠的转移储库和快速的治疗耐药。
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