CAR 疗法在肿瘤与自身免疫领域的演进:机制见解与治疗创新
The evolution of CAR therapies across oncology and autoimmunity: mechanistic insights and therapeutic innovations.
CD19靶向CAR-T疗法在系统性红斑狼疮的小型早期研究(通常为5-18例患者)中实现了深度B细胞清除和临床改善,使部分患者获得无药物缓解;
FRONTIER PAPERS
The evolution of CAR therapies across oncology and autoimmunity: mechanistic insights and therapeutic innovations.
CD19靶向CAR-T疗法在系统性红斑狼疮的小型早期研究(通常为5-18例患者)中实现了深度B细胞清除和临床改善,使部分患者获得无药物缓解;
CRISPR/Cas9 in cancer therapy: clinical translation, mechanistic strategies, and therapeutic directions.
CRISPR/Cas9基因组编辑技术的出现,通过促进对疾病相关遗传修饰的精确和可编程操控,显著改变了癌症治疗领域的格局。
CAR-T cell therapy in cancer immunotherapy - Biology, clinical successes, and emerging challenges: A review.
癌症免疫疗法通过使复发或难治性恶性肿瘤患者能够靶向激活抗肿瘤免疫应答,已彻底改变了肿瘤学领域。
Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors.
嵌合抗原受体(CAR)T细胞疗法已经彻底改变了血液系统恶性肿瘤的治疗,靶向CD19和BCMA的FDA批准疗法取得了显著的临床成功。
Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system.
嵌合抗原受体(CAR)-T细胞疗法是治疗血液系统恶性肿瘤的一项突破。
Engineering the next generation of CAR-NK immunotherapies.
在过去几年中,细胞免疫治疗已成为某些形式血液恶性肿瘤的新型治疗选择,多种CAR-T疗法现已在临床上常规应用。
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