靶向治疗或免疫治疗对转移性胰腺导管腺癌是否有效?
Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma?
15% 的肿瘤存在同源修复 DNA 损伤应答缺陷。
FRONTIER PAPERS
Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma?
15% 的肿瘤存在同源修复 DNA 损伤应答缺陷。
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features
MEKi+STAT3i 联合治疗可减轻基质炎症,并富集具有间充质干细胞样特性的 CAF 表型,从而克服 PDAC 中的免疫治疗耐药。
KRAS Inhibitors- yes but what next? Direct targeting of KRAS- vaccines, adoptive T cell therapy and beyond.
Kirsten 大鼠肉瘤病毒癌基因同源物(KRAS)是 RAS-MAPK 通路的原癌基因。
The next-generation KRAS inhibitors…What comes after sotorasib and adagrasib?
Kirsten 大鼠肉瘤病毒癌基因同源物(KRAS)是 20 世纪 80 年代初在人类癌症中最早被鉴定的驱动癌基因之一。
A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021.
作为一种具有巨大潜力和临床应用前景的抗肿瘤疗法,CAR-T 细胞疗法仍处于快速发展阶段。CAR-T 细胞相关领域在未来仍将是研究热点。
Gene Therapy: Transforming the Battle Against Pancreatic Cancer.
胰腺癌仍然是最具侵袭性和致死性的恶性肿瘤之一,尽管传统治疗方式取得了进展,但其预后仍然极差。
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