肿瘤细胞治疗研究
英文原题：A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021.
A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021.
作为一种具有巨大潜力和临床应用前景的抗肿瘤疗法，CAR-T细胞疗法仍处于快速发展阶段。CAR-T细胞相关领域在未来仍将是研究热点。
采用文献计量学和知识图谱分析，探索CAR-T细胞领域热点的演变和发展趋势。通过寻找研究热点和新主题，可为该领域研究人员提供新的线索和思路。
于2021年10月28日从Web of Science核心合集（WOSCC）中检索并获取了关于CAR-T细胞的文章和综述。使用CiteSpace[版本5.8.R3（64位）]和VOSviewer（版本1.6.17）进行文献计量学和知识图谱分析。
来自104个国家/地区的488个机构的660位作者在1,212种学术期刊上发表了6,867篇论文。美国在该研究领域处于绝对领先地位。发表论文最多的机构是宾夕法尼亚大学。Carl H June发表的文章最多，而Shannon L Maude的共被引次数最多。然而，国家之间的合作很少。2012年之后，各机构之间的合作也很少。发表CAR-T细胞相关论文最多的期刊是Frontiers in immunology和Cancers。然而，Blood和The New England Journal of Medicine是共被引最多的期刊。最具影响力的研究热点是CAR-T细胞在血液系统恶性肿瘤中的研究、细胞因子释放综合征（CRS）的相关研究、CD19，以及CAR-T细胞的抗肿瘤活性和疗效。最新的热点和主题包括CAR-T细胞在实体瘤中的研究、通用CAR-T细胞、CAR-NK细胞、CD22和anakinra（IL-1受体拮抗剂）。CAR-T细胞在实体瘤中的研究是一个快速发展的热门领域。该领域的新兴主题主要包括CAR-T细胞在胶质母细胞瘤（相关靶点：IL13R 2、EGFRvIII和HER2）、神经母细胞瘤（相关靶点：GD2）、肉瘤（相关靶点：HER2）和胰腺癌（相关靶点：mesothelin）中的研究，尤其是胶质母细胞瘤。
OBJECTIVES: A bibliometric and knowledge-map analysis is used to explore hotspots' evolution and development trends in the CAR-T cell field. By looking for research hotspots and new topics, we can provide new clues and ideas for researchers in this field. METHODS: The articles and reviews regarding CAR-T cells were retrieved and obtained from the Web of Science Core Collection (WOSCC) on October 28th, 2021. CtieSpace [version 5.8.R3 (64-bit)] and VOSviewer (version 1.6.17) were used to conduct the bibliometric and knowledge-map analysis. RESULTS: 660 authors from 488 institutions in 104 countries/regions published 6,867 papers in 1,212 academic journals. The United States was absolutely in the leading position in this research field. The institution that contributed the most publications was the University of Pennsylvania. Carl H June published the most articles, while Shannon L Maude had the most co-citations. However, there was little cooperation between countries. After 2012, cooperation among various institutions was also small. The journals that published the most CAR-T cell-related papers were Frontiers in immunology and Cancers . Nevertheless, Blood and The New England Journal of Medicine were the most commonly co-cited journals. The most influential research hotspots were the research of CAR-T cells in hematological malignancies, the related research of cytokine release syndrome (CRS), CD19, and the anti-tumor activity and efficacy of CAR-T cells. The latest hotspots and topics included the study of CAR-T cells in solid tumors, universal CAR-T cells, CAR-NK cells, CD22, and anakinra (the IL-1 receptor antagonist). The research of CAR-T cells in solid tumors was a rapidly developing hot field. Emerging topics in this field mainly included the study of CAR-T cells in glioblastoma (related targets: IL13R 2, EGFRvIII, and HER2), neuroblastoma (related target: GD2), sarcoma (related target: HER2), and pancreatic cancer (related target: mesothelin), especially glioblastoma. CONCLUSION: As an anti-tumor therapy with great potential and clinical application prospects, CAR-T cell therapy is still in a stage of rapid development. The related field of CAR-T cells will remain a research hotspot in the future.
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