可扩展生成靶向实体瘤的造血干细胞工程化现成单特异性细胞毒性 T 细胞
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性 T 细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA 限制和供者变异性等风险。
FRONTIER PAPERS
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors.
实体瘤的过继性 T 细胞治疗受到自体制造复杂性的限制,而在异体环境中还存在移植物抗宿主病(GvHD)、HLA 限制和供者变异性等风险。
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.
全球癌症负担日益加重,亟需创新的治疗策略。
Engineered TCR-T cells secreting IFNα/anti-PD-L1 potentiate endogenous immunity to synergistically bolster the efficacy against solid tumors.
T 细胞受体工程化 T 细胞(TCR-T)疗法是治疗实体瘤的一种有前景的方法。
Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer.
水凝胶赋能的过继细胞疗法(ACT)为改善实体瘤的细胞免疫治疗提供了一种局部且可控的策略。
Engineering Strategies for Allogeneic T Cell-Based Platforms in Cancer Immunotherapy.
异体 T 细胞疗法已成为一种有前景的策略,可克服自体疗法的物流和生产限制,实现可扩展的现货型癌症免疫治疗。
Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy.
膜锚定 IL15 与 IL21 的共表达是一项增强工程化 T 细胞抗实体瘤韧性与功能的技术,可能适用于多种治疗平台和疾病。
Progress in cell-based immunotherapies for solid tumors.
转化肿瘤学的进步得益于多种前沿技术的整合,包括细胞疗法、创新生物材料、控释系统、纳米医学和光疗。
Cell-based immunotherapies for solid tumors: advances, challenges, and future directions.
基于细胞的免疫疗法,包括 CAR-T、CAR-NK 和 TCR-T 疗法,通过提供对肿瘤细胞的精准靶向,代表了癌症治疗的变革性方法。
Current Situation and Prospect of Adoptive Cellular Immunotherapy for Malignancies.
过继细胞免疫治疗(ACT)是一种创新且有前景的肿瘤治疗方法。
Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.
异基因造血细胞移植(HCT)后复发和/或难治的急性髓系白血病(AML)通常致命。
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