CELL INTELLIGENCE · 肿瘤细胞治疗研究

通过计算机模拟-体外工作流程发现靶向 KRAS G12D 新抗原的 TCR 样抗体

Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow.

用于基于免疫的骨肉瘤治疗的创新纳米颗粒方法的现代趋势

Modern trends of using innovative nanoparticle approaches for immune-based osteosarcoma therapy.

骨肉瘤的系统性治疗策略：进展与未来方向

Systemic strategies for osteosarcoma: advances and future directions.

内膜肉瘤的基因组分析揭示了具有不同肿瘤微环境和治疗意义的分子亚型

Genomic profiling of intimal sarcoma reveals molecular subtypes with distinct tumor microenvironments and therapeutic implications.

我们确定了两种内膜肉瘤分子亚型。与 CNV-H 相比，MSI-H-like 富集于与肿瘤免疫应答和 TIL 相关的通路。需要进一步的努力和临床试验来更好地定义这些分子亚型，从而为个性化治疗方法开辟新途径并改善患者预后。

肉瘤免疫治疗：直面当前障碍并揭示未来机遇

Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities.

骨肉瘤 T 细胞免疫疗法的前景与挑战

Promise and Challenges of T Cell Immunotherapy for Osteosarcoma.

靶向肿瘤血管以改善经体外 T 细胞衔接双特异性抗体武装的 T 细胞的抗肿瘤活性

Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody.

软组织肉瘤的综合分子特征分析用于预测基于帕唑帕尼的治疗反应

Comprehensive Molecular Characterization of Soft Tissue Sarcoma for Prediction of Pazopanib-Based Treatment Response.

尽管研究人群和治疗存在异质性这一局限性，我们还是发现了可能预测帕唑帕尼疗效的分子标志物，可用于未来旨在评估治疗策略的临床试验中。

体外扩增γδ T 细胞对骨肉瘤细胞的治疗潜力

Therapeutic Potential of Ex Vivo Expanded γδ T Cells against Osteosarcoma Cells.

高级别子宫内膜间质肉瘤：分子改变及潜在免疫治疗策略

High-Grade Endometrial Stromal Sarcoma: Molecular Alterations and Potential Immunotherapeutic Strategies.