CELL INTELLIGENCE · 肿瘤细胞治疗研究

儿童实体瘤的嵌合抗原受体（CAR）-T 细胞疗法：当前突破、困境与策略

Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies.

双顺反子 CD19/CD22 CAR-T 细胞疗法治疗儿童 B 细胞急性淋巴细胞白血病：一项非随机临床试验

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: A Nonrandomized Clinical Trial.

在这项非随机临床试验中，双顺反子 CD19/CD22 CAR-T 细胞疗法在儿童 B-ALL 中诱导了高比例的微小残留病阴性缓解，并具有持久的 EFS。这些发现支持在前瞻性试验中进一步评估。

患者来源髓母细胞瘤类器官模型中肿瘤发生机制的阐明与免疫治疗疗效评估

Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patient-Derived Medulloblastoma Organoid Models.

H3 K27 变异型弥漫性中线胶质瘤时代的弥漫性内生性脑桥胶质瘤

Diffuse intrinsic pontine glioma in the era of H3 K27-altered diffuse midline glioma.

免疫功能低下宿主中耐药革兰阴性感染的新型抗生素：从关键试验到高风险实践

Newer antibiotics for drug-resistant Gram-negative infections in immunocompromised hosts: from pivotal trials to high-risk practice.

CAR-T 细胞治疗临床试验全景与发展趋势的全球多维分析

A global multidimensional analysis of the chimeric antigen receptor T-cell therapy clinical trial landscape and development trends.

白血病中纤维-微生物群-屏障轴的治疗生态学：韧性、免疫恢复与药物微生物组学

Therapeutic ecology of the fiber-microbiota-barrier axis in leukemia: resilience, immune recovery and pharmacomicrobiomics.

儿童单倍体相合异基因造血干细胞移植后 EB 病毒感染及移植后淋巴增殖性疾病的发生率和危险因素

Incidence and risk factors of Epstein-Barr virus infection and post-transplant lymphoproliferative disorder in paediatric haploidentical allogeneic he

供者来源 CD19 靶向 CAR-NK 细胞在 blinatumomab 和自体 CD19 靶向 CAR-T 治疗失败后诱导复发 B-ALL 患儿完全缓解

Donor-derived CD19-targeted CAR-NK cells induce complete remission in a child with relapsed B-ALL after failure of blinatumomab and autologous CD19-ta

骨肉瘤的基因免疫治疗：从溶瘤载体到工程化免疫细胞

Gene-based immunotherapy in osteosarcoma: from oncolytic vectors to engineered immune cells.