CELL INTELLIGENCE · 肿瘤细胞治疗研究

β-葡聚糖和 CD40 激动剂通过激活巨噬细胞和 NK 细胞抑制骨肉瘤肺转移

Inhibition of osteosarcoma lung metastases by β-glucan and CD40 agonist is mediated by activation of macrophages and NK cells.

我们的研究结果表明β-葡聚糖对 OS 肺肿瘤负荷具有抗肿瘤活性，β-葡聚糖与 CD40a 联合使用可增强治疗活性，且该活性由先天免疫（巨噬细胞和 NK 细胞）的激活所介导。

进入场景：T(H)9 细胞向肺部优越的迁移能力解释了其卓越的抗癌疗效

Go to the scene: T(H)9 cells superior migration ability to the lungs explains their exceptional anticancer efficacy.

RREB1 可作为免疫学和预后生物标志物：从综合分析到骨肉瘤验证

RREB1 could act as an immunological and prognostic biomarker: From comprehensive analysis to osteosarcoma validation.

RREB1 显示出作为某些癌症预后标志物的潜力，并可能预测免疫治疗的疗效。此外，RREB1 表达与免疫相关标志物相关，表明其在特定肿瘤的预后和预测免疫微环境治疗反应中发挥作用。

COPS6 通过抑制 IL-6 产生来促进肿瘤进展并减少 CD8(+) T 细胞浸润，从而促进乳腺癌的肿瘤免疫逃逸

COPS6 promotes tumor progression and reduces CD8(+) T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast can