CELL INTELLIGENCE · 肿瘤细胞治疗研究

基因调控元件决定 BCMA 靶向 CAR-T 细胞产品的疗效

Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products.

用于儿童实体瘤的 CAR-T 细胞疗法：装甲 CAR-T 细胞及其他

CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond.

CAR-T 治疗的疗效、安全性和成本效果

Efficacy, safety and cost-effectiveness of CAR-T therapy.

CAR-T 细胞治疗背景下的多发性骨髓瘤向髓系肉瘤转分化

Transdifferentiation From Multiple Myeloma to Myeloid Sarcoma in the Setting of CAR T-Cell Therapy.

靶向 CD70 的 CAR-T/NK 治疗：原理、进展和未来方向

CD70-targeted CAR-T/NK therapy: Rationale, advances, and future directions.

过继性细胞疗法治疗肉瘤的综述

Review of Adoptive Cellular Therapies for the Treatment of Sarcoma.

原发性皮肤肿瘤伴横纹肌肉瘤样分化及黑色素瘤样突变谱

Primary Cutaneous Neoplasm With Rhabdomyosarcomatous Differentiation and a Melanoma-Like Mutational Landscape.

肿瘤分泌的细胞外囊泡通过触发炎性间充质干细胞发育削弱治疗应答

Tumor-Secreted Extracellular Vesicles Counteract Therapy Response by Triggering Inflammatory Mesenchymal Stem Cell Development.

我们的观察结果确立了 iMSCs 是导致耐药性的主要因素，揭示了 EVs 是触发 iMSC 发展的因素，并强调了一种有前景的联合策略，以提高骨癌患者的治疗反应。

IL-11 工程化巨噬细胞膜包被的活性氧响应纳米颗粒用于靶向递送多柔比星至骨肉瘤

IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma.

通过 IL-8 引导 B7-H3 CAR-T 细胞归巢诱导对儿童肉瘤的强效抗肿瘤活性

Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma.

这些发现值得进一步研究 BC2 CAR-T 细胞用于治疗 RMS、OS 及其他表达 B7-H3、产生 IL-8 的实体瘤患者。