CELL INTELLIGENCE · 肿瘤细胞治疗研究

EGFRxCD16 双特异性抗体联合溶瘤病毒驱动 NK 细胞介导的卵巢癌与 NSCLC 细胞系高效裂解

EGFRxCD16 bispecific antibodies orchestrate superior NK cell-mediated lysis of ovarian cancer and NSCLC cell lines in combination with oncolytic virus

卵巢癌的免疫景观与肿瘤异质性：来自单细胞 RNA 测序的见解

Immune Landscape and Tumour Heterogeneity in Ovarian Cancer: Insights From Single-Cell RNA Sequencing.

靶向 PD-L1 和 ErbB2（HER2）的双重 CAR-NK 细胞表现出协同 CAR 信号传导并抵抗实体瘤异质性

Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.

同时靶向 PD-L1 与 ErbB2 可通过对抗原异质性提供抵抗力并经协同激活放大抗肿瘤信号，增强 CAR-NK 细胞对难治性实体瘤的疗效。

综合泛癌分析确定 POFUT1 作为与免疫逃逸相关的预后生物标志物和潜在治疗靶点

Comprehensive Pan-Cancer Analysis Identifies POFUT1 as a Prognostic Biomarker and Potential Therapeutic Target Associated with Immune Evasions.

这项泛癌研究确立了 POFUT1 是与侵袭性疾病、免疫逃逸和不良预后相关的关键致癌因子。其一致的过表达和功能影响凸显了其作为抗癌治疗生物标志物和靶点的潜力。尽管这些计算发现需要实验验证，但 POFUT1 已成为一个候选生物标志物，值得进行功能研究和潜在的治疗靶向。

二硫化钼处理与近红外辐射对人间充质干细胞的协同效应评估

Evaluation of Synergic Effects of Molybdenum Disulfide Treatment and Near-Infrared Radiation on Human Mesenchymal Stem Cells.

靶向间皮素的全人源嵌合抗原受体自体 T 细胞在表达间皮素的癌症中的 1 期研究

Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.

CRISPR 编辑细胞系：功能肿瘤学研究的新时代

CRISPR-Edited Cell Lines: A New Era in Functional Oncology Research.

工程化间充质干细胞-NK 细胞复合物用于空间靶向与功能重焕的肿瘤免疫治疗

Engineered Mesenchymal Stem Cell-NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy.

KIR2DL4 在癌症免疫治疗中的新兴作用

Emerging roles of KIR2DL4 in cancer immunotherapy.

三级淋巴结构通过重塑冷肿瘤微环境实现从冷到热的转变

Tertiary lymphoid structures achieve 'cold' to 'hot' transition by remodeling the cold tumor microenvironment.