肿瘤细胞治疗研究
英文原题：Evaluation of Synergic Effects of Molybdenum Disulfide Treatment and Near-Infrared Radiation on Human Mesenchymal Stem Cells.
研究结果提示，MoS2 的抗癌特性在 NIR 照射条件下得到增强。
引言：二硫化钼（MoS2）作为抗癌试剂，可在光疗中吸收近红外（NIR）波长。本研究通过蛋白质-蛋白质相互作用（PPI）网络分析，评估纳米结构MoS2与NIR辐射对人间充质干细胞（hMSC）的协同效应。 方法：从基因表达综合数据库（GEO）提取hMSC基因表达谱，并开展PPI网络分析。通过Kaplan-Meier Plotter评估结果的有效性。 结果：在识别出的121个差异表达基因（DEG）中，FN1、ACTA2、CCL2、CXCL8、FBN1和LEP被选为MoS2与NIR辐射协同作用的枢纽基因。Kaplan-Meier Plotter分析显示，MoS2与NIR辐射抑制FN1，可显著提高胃癌、肺癌、卵巢癌和骨髓瘤患者的总生存期。 结论：研究结果表明，NIR辐射条件下MoS2的抗癌特性增强。因此，MoS2是光动力治疗中适用的光敏剂。
Introduction: Molybdenum disulfide (MoS2), as an anticancer reagent, can absorb near-infrared (NIR) wavelengths in phototherapy. In the present study, the synergic effect of MoS2 (in nanostructure) and NIR radiation on human mesenchymal stem cells (hMSCs) was evaluated via protein-protein interaction (PPI) network analysis. Methods: Gene expression profiles of hMSCs were extracted from the Gene Expression Omnibus (GEO) database and analyzed via PPI network analysis. The validity of findings was assessed via the Kaplan-Meier Plotter. Results: FN1, ACTA2, CCL2, CXCL8, FBN1, and LEP genes were selected as hub genes among 121 recognized differentially expressed genes (DEGs) as the targeted genes by the synergic effects of MoS2 and NIR radiation. Kaplan-Meier Plotter analysis demonstrated that FN1 suppression by MoS2 and NIR radiation can significantly increase the overall survival of patients with gastric cancer, lung cancer, ovarian cancer, and myeloma. Conclusion: In conclusion, findings indicate that the anticancer property of MoS2 is intensified in the condition of NIR radiation. Therefore, MoS2 is a suitable photosensitizer reagent in photodynamic therapy.
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