下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Tumour immunotherapy in solid and hematologic malignancies: Progress, challenges, and a practical framework.
肿瘤免疫治疗通过将免疫监视、免疫编辑和检查点生物学的基础见解转化为有效的临床策略,重塑了肿瘤学的格局。
Bispecific CAR-T cells targeting CD19/20 in patients with relapsed or refractory B cell non-Hodgkin lymphoma: a phase I/II trial.
非霍奇金淋巴瘤(NHL)是血液系统常见的恶性肿瘤,传统治疗对复发/难治性NHL(R/R NHL)患者疗效有限,尤其是弥漫大B细胞淋巴瘤(DLBCL)患者。
Bispecific antibodies and autologous chimeric antigen receptor T cell therapies for treatment of hematological malignancies.
近年来,血液系统恶性肿瘤的治疗格局取得了显著进展,尤其是自2017年自体CAR-T 细胞疗法首次获批用于复发/难治性急性淋巴细胞白血病(ALL)以来。
A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies.
双特异性T细胞衔接器(bsTCEs)在癌症治疗中具有巨大前景,但由于诱导细胞因子释放综合征(CRS)、靶向非肿瘤毒性以及参与限制疗效的免疫抑制性调节性T细胞,其应用面临挑战。
CAR-T cell therapy in cancer immunotherapy - Biology, clinical successes, and emerging challenges: A review.
癌症免疫疗法通过使复发或难治性恶性肿瘤患者能够靶向激活抗肿瘤免疫应答,已彻底改变了肿瘤学领域。
Advancements in Personalized CAR-T Therapy: Comprehensive Overview of Biomarkers and Therapeutic Targets in Hematological Malignancies.
CAR-T 细胞疗法是一种使用自体或异体T细胞的新型抗癌疗法。
Cardiotoxic profiles of CAR-T therapy and bispecific T-cell engagers in hematological cancers.
Tisagenlecleucel与严重和致命的不良心脏事件相关,在DLBCL患者中,与axicabtagene ciloleucel相比,低血压的致死率更高,但在儿童ALL患者中,与blinatumomab相比,低血压致死率相似。
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments.
传统癌症治疗使用非特异性药物和单克隆抗体靶向肿瘤细胞。
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently.
CD19 嵌合抗原受体(CAR)T 细胞在复发和难治性急性淋巴细胞白血病(R/R ALL)中显示出强大疗效,但在慢性淋巴细胞白血病(CLL)和非霍奇金淋巴瘤(NHL)中结果不佳。
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