双重靶向肿瘤代谢组和应激抗原影响工程化 T 细胞的转录组异质性和疗效
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.
少数癌症可以通过工程化T细胞策略有效靶向。
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FOR TREATMENT
按「中国试验优先 → 正在招募 → 更新更近」排序。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.
少数癌症可以通过工程化T细胞策略有效靶向。
BiTE-Secreting CAR-γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors.
HLA-G 被认为是一种免疫检查点蛋白和肿瘤相关抗原。
Activation of an adaptive antitumor immune response by the polymeric fluoropyrimidine CF10 involves TS/Top1 dual targeting.
在体内,对携带原位MC38肝转移的C57BL/6小鼠进行CF10治疗,可增加CD4⁺、CD8⁺和γδ T细胞浸润,减少髓源性抑制细胞(MDSCs),并降低肝脏肿瘤负荷。
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