不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
原发性纵隔 B 细胞淋巴瘤的诊断与管理：英国血液学会指南
英文原题：The diagnosis and management of primary mediastinal B-cell lymphoma: A British Society for Haematology guideline.
查看英文原题
The diagnosis and management of primary mediastinal B-cell lymphoma: A British Society for Haematology guideline.
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中文摘要
原发性纵隔B细胞淋巴瘤（PMBCL）是侵袭性B细胞淋巴瘤谱系中一种独特的临床病理实体，具有独特的临床、免疫表型和分子特征。自2019年英国血液学会（BSH）良好实践文件发表以来，影像学、放疗方法和系统性治疗方面取得了重要进展，包括嵌合抗原受体（CAR）T细胞治疗和免疫检查点抑制。关键更新包括采用PET适应性方法指导一线化学免疫治疗后的放疗决策，对达到完全代谢缓解的患者省略巩固性放疗。该指南强调剂量密集型化学免疫治疗方案的重要性，并为化学免疫治疗后PET-CT影像显示Deauville评分4分（DS4）和DS5分缓解状态患者的临床管理提供了框架。
展开英文摘要原文
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B-cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematology (BSH) Good Practice Paper, there have been important advances in imaging, radiotherapy approaches and systemic therapies, including chimeric antigen receptor (CAR) T-cell therapy and immune checkpoint inhibition.
Key updates include the use of PET-adapted approaches to guide radiotherapy decisions following first-line chemoimmunotherapy, with omission of consolidative radiotherapy in patients achieving complete metabolic response. The guideline emphasises the importance of dose-intensive chemoimmunotherapy regimens and provides a framework for the clinical management of patients with Deauville stage 4 (DS4) and DS5 response status on PET-CT imaging following chemoimmunotherapy.
论文信息
- 作者
- Osborne W、Bielby H、Cwynarski K、El-Sharkawi D、Petrides G、Illidge T、Mikhaeel NG、Burton C
- 第一作者单位
- Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.United Kingdom
- 通讯作者单位
- Cancer Sciences, University of Southampton, Southampton, UK.United Kingdom
- 期刊
- British journal of haematology2026 Aug 23
- 原文标识
- PubMed 42634099 · DOI 10.1111/bjh.70768