CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胆囊癌中肿瘤出芽和 TIL（肿瘤浸润淋巴细胞）的预后意义
英文原题：Prognostic Significance of Tumour Budding and Tumour-infiltrating Lymphocytes in Gallbladder Carcinoma.
查看英文原题
Prognostic Significance of Tumour Budding and Tumour-infiltrating Lymphocytes in Gallbladder Carcinoma.
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研究概要
年龄、较低分化的组织学分级、pT 分期、LVI 和较高的 TB 分级与较差的 4 年总生存期独立相关。较高的 TB 与高风险临床病理特征和较差的总生存期相关，而较高的 TILs 与较低的 GBC 组织学分级和 LVI 发生率相关。
研究思路结论见上方概要
胆囊癌（GBC）常在晚期发生，其组织学亚型、肿瘤大小、分化程度、淋巴血管侵犯（LVI）、神经周围侵犯（PNI）、淋巴结转移和手术切缘均影响预后。肿瘤出芽（TB）和TIL（肿瘤浸润淋巴细胞）（TILs）已成为多种癌症中的新型预后标志物。
研究纳入2016年1月至2022年5月期间手术切除的胆囊标本。临床资料从机构档案中检索。对组织病理学切片进行复核，评估组织学分化、颈部切缘状态、LVI、PNI、浆膜受累、淋巴结转移等。TILs和TB按照既定指南进行分级。使用Statistical Package for Social Sciences 21.0版进行数据分析。
对79例胆囊腺癌（pT1 = 25.32%，pT2 = 34.18%，pT3 = 40.50%）病例进行了检查。手术切缘、LVI、PNI、浆膜受累和淋巴结转移分别存在于13.92%（11/79）、26.58%（21/79）、29.11%（23/79）、41.77%（33/79）和30.38%（24/79）的病例中；43.04%（34/79）、36.71%（29/79）和20.25%（16/79）的病例分别为TIL-1、TIL-2和TIL-3。Bd1、Bd2和Bd3分别在63.29%（50/79）、18.99%（15/79）和17.72%（14/79）的病例中被观察到。较高等级的TB与较差的肿瘤组织学（P < 0.001）、较高的病理分期（P = 0.044）、手术颈部切缘受累（P < 0.001）、LVI（P < 0.001）、PNI（P < 0.001）、浆膜受累（P = 0.013）和淋巴结转移（P = 0.009）相关。高TILs预示较低的组织病理学分级（P = 0.012）和LVI（P = 0.015）。
展开英文摘要原文
Gallbladder cancer (GBC) frequently occurs at an advanced stage, with histological sub-type, tumour size, grade of differentiation, lymphovascular invasion (LVI), perineural invasion (PNI), nodal metastases, and surgical resection margins impacting prognosis. Tumour budding (TB) and tumour-infiltrating lymphocytes (TILs) have emerged as novel prognostic markers in various cancers.
The study included gallbladder specimens operated between January 2016 and May 2022. Clinical data were retrieved from the institutional archive. Histopathological slides were reviewed for histological differentiation, neck resection margin status, LVI, PNI, serosal involvement, lymph node metastases, etc. TILs and TB were graded according to established guidelines. Statistical Package for Social Sciences version 21.0 was utilised to analyse the data.
Seventy-nine gallbladder adenocarcinoma (pT1 = 25.32%, pT2 = 34.18%, pT3 = 40.50%) cases were examined. Surgical resection margin, LVI, PNI, serosal involvement, and nodal metastasis were present in 13.92% (11/79), 26.58% (21/79), 29.11% (23/79), 41.77% (33/79), and 30.38% (24/79) cases, respectively; 43.04% (34/79), 36.71% (29/79), and 20.25% (16/79) of cases had TIL-1, TIL-2, and TIL-3, respectively. Bd1, Bd2, and Bd3 were noted in 63.29% (50/79), 18.99% (15/79), and 17.72% (14/79), of cases, respectively. Higher-grade TB was linked with poorer tumour histology ( P < 0.001), higher pathological stage ( P = 0.044), surgical neck resection margin involvement ( P < 0.001), LVI ( P < 0.001), PNI ( P < 0.001), serosal involvement ( P = 0.013), and nodal metastasis ( P = 0.009). High TILs predicted lower histopathological grades ( P = 0.012) and LVI ( P = 0.015).
Age, less differentiated histological grade, pT category, LVI, and higher TB grade were independently associated with worse 4-year overall survival. Higher TB correlates with high-risk clinicopathological features and inferior overall survival, while higher TILs are associated with lower GBC histological grade and LVI incidence.
论文信息
- 作者
- Singh A、Prasad P、Singh A、Singh A
- 第一作者单位
- Department of Pathology and, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.India
- 通讯作者单位
- Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.India
- 期刊
- Journal of the West African College of Surgeons2026 Jul-Sep
- 原文标识
- PubMed 42445769 · DOI 10.4103/jwas.jwas_173_24
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