CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
BCMA CAR-T 用于淋巴浆细胞性淋巴瘤浆细胞复发后的 AL 淀粉样变性
英文原题：BCMA CAR T for AL Amyloidosis After Plasmacytic Relapse of Lymphoplasmacytic Lymphoma.
查看英文原题
BCMA CAR T for AL Amyloidosis After Plasmacytic Relapse of Lymphoplasmacytic Lymphoma.
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研究概要
该病例凸显了 LPL 相关 AL 淀粉样变性的生物学复杂性，并支持使用 BCMA 靶向治疗，尤其是当复发或残留病灶由浆细胞成分构成时。
中文摘要
方法
本文报告一例LPL相关AL淀粉样变患者病例。患者既往接受多种靶向B细胞及浆细胞的治疗方案。复发时，病理显示浆细胞样组织学特征；免疫组化可见浆细胞表达BCMA，且未检出B细胞浸润。患者随后接受研究性靶向B细胞成熟抗原（BCMA）的嵌合抗原受体（CAR）T细胞治疗。
结果
接受BCMA靶向CAR-T 治疗后，患者获得血液学完全缓解。
结论
本病例凸显了LPL相关AL淀粉样变的生物学复杂性，并支持使用BCMA靶向治疗，尤其当复发或残留病变由浆细胞成分构成时。 试验注册：ClinicalTrials.gov注册号NCT06097832。
展开英文摘要原文
METHODS
Here we describe the case of a patient with a history of LPL-associated AL amyloidosis who had previously been treated with multiple B-cell- and plasma-cell-directed regimens. At the time of relapse, pathology demonstrated plasmacytic histology, with BCMA-expressing plasma cells by immunohistochemistry and no detectable B-cell infiltrate. The patient subsequently received investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy.
RESULTS
Following BCMA-directed CAR T-cell therapy, the patient achieved a complete hematologic response.
CONCLUSION
This case highlights the biologic complexity of LPL-associated AL amyloidosis and supports the use of BCMA-targeted therapy, especially when the relapsing or residual disease is comprised by the plasma cell component. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT06097832.
论文信息
- 作者
- Al Haddad N、Brailovski E、Dela-Pena J、Cook M、Rosenzweig M、Jolie Landau H
- 第一作者单位
- Division of Nephrology Memorial Sloan Kettering Cancer Center New York City New York USA.United States
- 通讯作者单位
- Division of Hematology/Oncology Memorial Sloan Kettering Cancer Center New York City New York USA.United States
- 期刊
- EJHaem2026 Jun
- 原文标识
- PubMed 42312318 · DOI 10.1002/jha2.70329
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