CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Advances in deciphering intratumoral versus peritumoral heterogeneity of infiltrating lymphocytes in pancreatic cancer: a spatial perspective.
Advances in deciphering intratumoral versus peritumoral heterogeneity of infiltrating lymphocytes in pancreatic cancer: a spatial perspective.
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胰腺导管腺癌（PDAC）仍是致死率最高的恶性肿瘤之一，具有显著免疫抑制和空间异质性的肿瘤微环境。近期研究重点关注TIL（肿瘤浸润淋巴细胞）在肿瘤内和肿瘤周围区室中的不同空间分布。本综述总结最新进展，阐明区域特异性TIL亚群的分布、功能状态和起源，并剖析空间异质性如何推动疾病进展和免疫治疗耐药。我们进一步探讨免疫抑制性基质与淋巴细胞异质性之间的双向相互作用，重点介绍当前技术和概念挑战，并概述有望塑造下一阶段发现的新兴技术。本研究为加速PDAC免疫肿瘤学转化提供了全面路线图。
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a profoundly immunosuppressive and spatially heterogeneous tumor microenvironment. Recent research has focused on the distinct topographic distribution of tumor-infiltrating lymphocytes (TILs) across intratumoral and peritumoral compartments.
This review synthesizes the latest advances, delineating the distribution, functional states, and ontogeny of region-specific TIL subsets, and dissects how spatial heterogeneity fuels disease progression and resistance to immunotherapy.
We further explore the reciprocal crosstalk between immunosuppressive stroma and lymphocyte heterogeneity, highlight prevailing technical and conceptual challenges, and outline emerging technologies poised to shape the next phase of discovery. This work provides a comprehensive roadmap to accelerate translation in PDAC immuno-oncology.
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