CELL INTELLIGENCE · 肿瘤细胞治疗研究

CELLIN 肿瘤细胞治疗研究

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NK 细胞联合化疗增强胃癌治疗疗效

英文原题：Enhanced efficacy of gastric cancer treatment by a combination of NK cells and chemotherapy.

查看英文原题

Enhanced efficacy of gastric cancer treatment by a combination of NK cells and chemotherapy.

PubMed 2026/04/27（内容时间） iScience Q1 · IF 4.5（JCR 2025）

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技术：NK 细胞胃癌地区：中国
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中文摘要

NK细胞具有强效抗肿瘤活性，但由于肿瘤浸润不足和功能障碍，其治疗胃癌（GC）的疗效有限。为克服这一问题，我们研究了将NK细胞（由健康供者PBMC扩增）与化疗（奥沙利铂+氟尿嘧啶）联合的治疗潜力。体外实验中，低剂量化疗显著上调胃癌细胞上的活化配体，尤其是死亡受体，从而增强NK细胞细胞毒性。体内实验中，化疗促进NK细胞增殖、持久存留和肿瘤浸润，同时调节免疫抑制性微环境。联合疗法显著提高了多种胃癌模型中的治疗效果，且未增加化疗相关毒性，反而减轻了体重下降和白细胞减少。这些发现支持化疗联合NK细胞作为一种有前景的胃癌治疗策略。

展开英文摘要原文

NK cells demonstrate potent antitumor activity but show limited efficacy in gastric cancer (GC) due to poor tumor infiltration and dysfunction. To overcome this, we investigated the therapeutic potential of combining NK cell (expanded from healthy donor PBMCs) with chemotherapy (oxaliplatin + fluorouracil). In vitro , low-dose chemotherapy significantly upregulated activating ligands, particularly death receptors, on GC cells, enhancing NK cell cytotoxicity.

In vivo , chemotherapy promoted NK cell proliferation, persistence, and tumor infiltration while modulating the immunosuppressive microenvironment. The combination therapy significantly improved therapeutic efficacy across GC models without increasing chemotherapy-related toxicity, instead alleviating weight loss and leukopenia.

These findings support chemo-NK cell combination as a promising GC treatment strategy.

论文信息

作者
Yue J、Ma J、Li Y、Dong H、He Y、Chen M、Fang F、Xiao W
单位
Key Laboratory of Immune Response and Immunotherapy, The First Affiliate Hospital of USTC, Division of Life Sciences and Medicine, School of Basic Medical Sciences, University of Science and Technology of China, Hefei, Anhui 230021, China.China
期刊
iScience2026 Jun 19
原文标识
PubMed 42205691　·　DOI 10.1016/j.isci.2026.115915

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