CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
急性髓系白血病中的免疫治疗：在通往治愈的艰难道路上的抗体、TriKEs 和 CARs
英文原题：Immunotherapy in acute myeloid leukemia: The antibodies, TriKEs, and CARs on the arduous road to cure.
查看英文原题
Immunotherapy in acute myeloid leukemia: The antibodies, TriKEs, and CARs on the arduous road to cure.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
急性髓系白血病（AML）是一种复杂、异质性且侵袭性强的造血克隆性疾病，除异基因干细胞移植外，治愈选择有限。由于高复发率、化疗耐药以及免疫抑制性肿瘤微环境，该病带来了重大挑战。免疫系统在白血病存活和耐药中发挥重要作用。目前正在测试多种免疫治疗策略，包括单克隆抗体、抗体药物偶联物（ADCs）、双特异性T细胞衔接器（BiTE）、CAR-T（CAR-T）细胞、疫苗以及NK细胞治疗性输注，结果令人鼓舞但存在矛盾。我们从临床血液科医生的角度，综述了处于临床前和临床开发阶段的各类免疫治疗，并讨论了如何在临床实践中最佳使用它们。
展开英文摘要原文
Acute myeloid leukemia (AML) is a complex, heterogeneous and aggressive hematopoietic clonal disorder with limited curative options beyond allogeneic stem cell transplantation. The disease presents significant challenges due to high relapse rates resistance to chemotherapy, and the immunosuppressive tumor microenvironment.
The immune system plays an important role in leukemia survival and resistance. Various immunotherapeutic approaches, ranging from the use of monoclonal antibodies, antibody-drug conjugates (ADCs), bispecific T-cell engagers (BiTE's), chimeric antigen receptor T (CAR-T) cells, vaccines and therapeutic infusions of NK cells, are currently being tested with promising, yet conflicting results.
We review the various types of immunotherapies in pre-clinical and clinical development and discuss how best to use them in clinical practice from the point of view of a clinical hematologist.
论文信息
- 作者
- Adhikari B、Litzow MR、Dias AL
- 第一作者单位
- Division of Hematology, National Heart, Lung and Blood Institute, Bethesda, MD, USA.United States
- 通讯作者单位
- Immune Deficiency-Cellular Therapy Program, National Cancer Institute, Bethesda, MD, USA. Electronic address: ajoydias@gmail.com.United States
- 文献类型
- 综述
- 期刊
- Blood reviews2026 Jul
- 原文标识
- PubMed 42034501 · DOI 10.1016/j.blre.2026.101391
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →