CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
工程化巨噬细胞用于癌症免疫治疗：新兴见解与治疗潜力
英文原题：Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.
查看英文原题
Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
巨噬细胞通过其可适应的表型以及对机械和生化信号的响应，强烈影响癌症进展。它们在肿瘤中的丰富存在以及与不良预后的关联，激发了人们对巨噬细胞靶向疗法的兴趣。本综述重点介绍巨噬细胞力学生物学、关键行为，以及工程化巨噬细胞的潜力，利用遗传性（CAR）或非遗传性“特洛伊木马”和“背包”策略，递送治疗并重塑免疫抑制性肿瘤微环境。
展开英文摘要原文
Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic "Trojan horse" and "backpacking" strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.
论文信息
- 作者
- Block A、Liu X、Zhang D、Adebowale K
- 第一作者单位
- Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.United States
- 通讯作者单位
- Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. kadebowale@ucsd.edu.United States
- 文献类型
- 综述
- 期刊
- npj biomedical innovations2026 Mar 2
- 原文标识
- PubMed 42032323 · DOI 10.1038/s44385-026-00072-y
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →